| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Epsin 2 |
| Specificity: |
This antibody reacts specifically with Epsin 2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Epsin 2 |
| Gene ID: |
22905 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Both epsin and Eps15 have an ubiquitous tissue distribution but are concentrated in presynaptic nerve terminals specialized for the Clathrin-mediated endocytosis of synaptic vesicles, Disruption of epsin function blocks Clathrin-mediated endocytosis, Epsin, Epsin 2a, Epsin is a binding partner to Eps15, Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer, Two novel EGF receptor substrates have been described, along with its binding partner Eps15, and 2b are splicing variants of epsin 2, designated EGF-receptor pathway substrates 8 and 15, is proposed to be involved in the assistance of Clathrin coat rearrangement during Clathrin coated pit invagination, or Eps8 and Eps15, which is associated with Clathrin-mediated endocytosis and are enriched in the brain in the peri-Golgi region, Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA1065 EHB21 |
| Also known as: |
Epsin 2 Polyclonal Antibody |
| Other name: |
Anti-Epsin 2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Epsin 2 |
| Short name: |
Anti-Epsin 2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Epsin 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
18639 |
| Gene: |
EPN2 |
More about : EPN2 |
| Long gene name: |
epsin 2 |
| Synonyms name: |
Eps15 binding protein |
| Locus: |
17p11, 2 |
| Discovery year: |
2002-05-14 |
| GenBank acession: |
AB028988 |
| Entrez gene record: |
22905 |
| Pubmed identfication: |
10567358 |
| RefSeq identity: |
NM_014964 |
| Havana BLAST/BLAT: |
OTTHUMG00000187034 |