| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
EDAR |
| Specificity: |
This antibody reacts specifically with EDAR |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human EDAR |
| Gene ID: |
10913 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Both EDAR and XEDAR exhibit homology with TROY, EDA-A1, EDA-A2, EDAR is encoded by the downless gene and is mutated in ectodermal dysplasia syndromes, Ectodysplasin A (EDA) is a type II membrane protein that is encoded by the Tabby gene and produces many splice variants, Members of the TNFR superfamily transmit signals through protein-protein interactions, The ectodermal dysplasia receptor (EDAR) promotes all three of these pathways and mediates ectodermal differentiation, These proteins share homology for cysteine-rich repeats in the extracellular ligand binding domain and an intracellular death domain, and these signals can lead to the activation of either the caspase and Jun kinase pathways, binds only the X-linked ectodysplasin-A2 receptor (XEDAR), differentiation and programmed cell death, including proliferation, or the NFÎ, serves as the ligand for EDAR, teeth and sweat gland development, the longest of which, which are characterized by impaired hair, which differs from EDA-A1 by the deletion of two amino acids, which promote cell death, which results in cell survival, º, B pathway, The tumor necrosis factor receptor (TNFR) superfamily represents a growing family of type I transmembrane glycoproteins that are involved in various cellular functions |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ED5 EDA3 Edar ED1R EDA1R |
| Also known as: |
EDAR Polyclonal Antibody |
| Other name: |
Anti-EDAR Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
EDAR |
| Short name: |
Anti-EDAR (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-ectodysplasin A receptor (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
DL and ECTD10A and ECTD10B and ED1R and ED3 and ED5 and EDA-A1R and EDA1R and EDA3 and HRM1, EDAR and IDBG-634358 and ENSBTAG00000019628 and 613947, EDAR and IDBG-65178 and ENSG00000135960 and 10913, Edar and IDBG-153317 and ENSMUSG00000003227 and 13608, Plasma membranes, protein binding, this GO :0001942 and hair follicle development and biological process this GO :0004872 and receptor activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008544 and epidermis development and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0030154 and cell differentiation and biological process this GO :0042346 and positive regulation of NF-kappaB import into nucleus and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0043473 and pigmentation and biological process this GO :0045177 and apical part of cell and cellular component this GO :0060662 and salivary gland cavitation and biological process, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005515 : protein binding, this GO :0004888 : transmembrane signaling receptor activity, this GO :0005515 : protein binding, ectodysplasin A receptor |
| Identity: |
2895 |
| Gene: |
EDAR |
More about : EDAR |
| Long gene name: |
ectodysplasin A receptor |
| Synonyms gene: |
ED3 DL |
| Synonyms gene name: |
anhidrotic receptor , ectodysplasin 1 |
| Locus: |
2q13 |
| Discovery year: |
1999-08-09 |
| GenBank acession: |
AF130988 |
| Entrez gene record: |
10913 |
| Pubmed identfication: |
10431241 9375732 |
| Classification: |
Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000130982 |