| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CYP1B1 |
| Specificity: |
This antibody reacts specifically with CYP1B1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CYP1B1 |
| Gene ID: |
1545 |
| Swiss Prot: |
Q16678 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression, In liver microsomes, It oxidizes a variety of structurally unrelated compounds, Plays an important role in the regulation of perivascular cell proliferation, Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, Promotes angiogenesis by removing cellular oxygenation products, These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis, and a variety of procarcinogenic compounds to their activated forms, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, cell adhesion and capillary morphogenesis, during angiogenesis, fatty acids, including polycyclic aromatic hydrocarbons, including steroids, migration, release of antiangiogenic factor THBS2, retinoid and xenobiotics, then allowing endothelial cells migration, thereby decreasing oxidative stress, this enzyme is involved in an NADPH-dependent electron transport pathway, Cytochromes P450 are a group of heme-thiolate monooxygenases |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CP1B |
| Also known as: |
CYP1B1 Polyclonal Antibody |
| Other name: |
Anti-CYP1B1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CYP1B1 |
| Short name: |
Anti-CYP1B1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CYP1B1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
2597 |
| Gene: |
CYP1B1 |
More about : CYP1B1 |
| Long gene name: |
cytochrome P450 family 1 subfamily B member 1 |
| Synonyms gene: |
GLC3A |
| Synonyms gene name: |
cytochrome P450, family 1, polypeptide 1 , polypeptide 1 (glaucoma 3, primary infantile) cytochrome P450, subfamily B, subfamily I (dioxin-inducible) |
| Locus: |
2p22, 2 |
| Discovery year: |
1994-12-20 |
| GenBank acession: |
U56438 |
| Entrez gene record: |
1545 |
| Pubmed identfication: |
8175734 15128046 |
| RefSeq identity: |
NM_000104 |
| Classification: |
Cytochrome P450 family 1 |
| Havana BLAST/BLAT: |
OTTHUMG00000100970 |
| Locus Specific Databases: |
Human Cytochrome P450 (CYP)Allele Nomenclature Committee |