| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
NFKBIA/IKB alpha |
| Specificity: |
This antibody reacts specifically with NFKBIA/IKB alpha |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from mouse IKB alpha |
| Gene ID: |
18035 |
| Swiss Prot: |
Q9Z1E3 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription, Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
IKBA MAD-3 IkappaBalpha |
| Also known as: |
NFKBIA/IKB alpha Polyclonal Antibody |
| Other name: |
Anti-NFKBIA/IKB alpha Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
NFKBIA/IKB alpha |
| Short name: |
Anti-NFKBIA/IKB alpha (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, a/IKB a (polyclonal), antibody to-nuclear factor on kappa light polypeptide gene enhancer in B-cells inhibitor |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BIKBA and IDBG-632547 and ENSBTAG00000016683 and 282291, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0051059 and NF-kappaB binding and molecular function this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0070417 and cellular response to cold and biological process this GO :0070427 and nucleotide-binding oli this GO merization domain containing 1 signaling pathway and biological process this GO :0070431 and nucleotide-binding oli this GO merization domain containing 2 signaling pathway and biological process, IKBA and MAD-3 and NFKBI, NF-kappaB binding, NFKBIA and IDBG-4758 and ENSG00000100906 and 4792, Nfkbia and IDBG-140708 and ENSMUSG00000021025 and 18035, alpha, nuclei, this GO :0000060 and protein import into nucleus, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0008139 : nuclear localization sequence binding and also this GO :0019899 : enzyme binding and also this GO :0031072 : heat shock protein binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0032403 : protein complex binding and also this GO :0042802 : identical protein binding and also this GO :0051059 : NF-kappaB binding, this GO :0008134 : transcription factor binding, this GO :0008139 : nuclear localization sequence binding, this GO :0019899 : enzyme binding, this GO :0031072 : heat shock protein binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0032403 : protein complex binding, this GO :0042802 : identical protein binding, this GO :0051059 : NF-kappaB binding, translocation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007253 and cytoplasmic sequestering of NF-kappaB and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008139 and nuclear localization sequence binding and molecular function this GO :0010468 and regulation of gene expression and biological process this GO :0010745 and negative regulation of macrophage derived foam cell differentiation and biological process this GO :0010875 and positive regulation of cholesterol efflux and biological process this GO :0010888 and negative regulation of lipid storage and biological process this GO :0016032 and viral process and biological process this GO :0019899 and enzyme binding and molecular function this GO :0031072 and heat shock protein binding and molecular function this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031663 and lipopolysaccharide-mediated signaling pathway and biological process this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032270 and positive regulation of cellular protein metabolic process and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032495 and response to muramyl dipeptide and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0033256 and I-kappaB/NF-kappaB complex and cellular component this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042345 and regulation of NF-kappaB import into nucleus and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042994 and cytoplasmic sequestering of transcription factor and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043330 and response to exogenous dsRNA and biological process this GO :0043392 and negative regulation of DNA binding and biological process this GO :0045087 and innate immune response and biological process this GO :0045638 and negative regulation of myeloid cell differentiation and biological process this GO :0045746 and negative regulation of Notch signaling pathway and biological process this GO :0045893 and positive regulation of transcription, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor |
| Identity: |
7797 |
| Gene: |
NFKBIA |
More about : NFKBIA |
| Long gene name: |
NFKB inhibitor alpha |
| Synonyms gene: |
NFKBI |
| Synonyms gene name: |
alpha , nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor |
| Synonyms name: |
NF-kappa-B inhibitor alpha |
| Locus: |
14q13, 2 |
| Discovery year: |
1992-02-13 |
| Entrez gene record: |
4792 |
| Pubmed identfication: |
1829648 |
| RefSeq identity: |
NM_020529 |
| Classification: |
Ankyrin repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000140220 |
| Locus Specific Databases: |
NFKBIAbase: Mutation registry for Autosomal dominant anhidrotic ectodermal dysplasia and T-cell immunodeficiency LRG_89 |