| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GRINA |
| Specificity: |
This antibody reacts specifically with GRINA |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Transmembrane |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GRINA |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
As one of the four major proteins of the NMDA receptor ion channel, CREB function and gene regulation, Due to the chromosomal location of the gene encoding GRINA, GRINA (Glutamate [NMDA] receptor-associated protein 1), Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, Synaptic and extrasynaptic NMDA receptors have been shown to have opposite effects on neuronal survival, also designated NMDA receptor glutamate-binding subunit or putative MAPK-activating protein PM02, both of which contain glutamate-gated, cation-specific ion channels, is a 371 amino acid multi-pass transmembrane protein, neural development and neurodegeneration, studies have linked possible GRINA involvement with a form of idiopathic generalized epilepsy, Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HNRGW TMBIM3 LFG1 |
| Also known as: |
GRINA Polyclonal Antibody |
| Other name: |
Anti-GRINA Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GRINA |
| Short name: |
Anti-GRINA (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-GRINA (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4589 |
| Gene: |
GRINA |
More about : GRINA |
| Long gene name: |
glutamate ionotropic receptor NMDA type subunit associated protein 1 |
| Synonyms gene: |
NMDARA1 |
| Synonyms gene name: |
N-methyl D-aspartate-associated protein 1 (glutamate binding) , glutamate receptor, ionotropic |
| Synonyms name: |
transmembrane BAX inhibitor motif containing 3 |
| Locus: |
8q24, 3 |
| Discovery year: |
1992-12-15 |
| GenBank acession: |
NM_001009184 |
| Entrez gene record: |
2907 |
| Pubmed identfication: |
1719427 8406459 |
| RefSeq identity: |
NM_001009184 |
| Classification: |
Transmembrane BAX inhibitor motif containing |
| Havana BLAST/BLAT: |
OTTHUMG00000165433 |