| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CACNA1G + CACNA1H |
| Specificity: |
This antibody reacts specifically with CACNA1G + CACNA1H |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from CACNA1G + CACNA1H |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation, T-type calcium channels belong to the ", T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle, The isoform alpha-1G gives rise to T-type calcium currents, There are 2 isoforms of CACNA1H and 14 isoforms if CACNA1G, They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes, cell division and cell death, cell motility, gene expression, group and are strongly blocked by mibefradil, hormone or neurotransmitter release, including muscle contraction, produced by alternative splicing, Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, low-voltage activated (LVA)" |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Cav3, 2 |
| Also known as: |
CACNA1G + CACNA1H Polyclonal Antibody |
| Other name: |
Anti-CACNA1G + CACNA1H Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CACNA1G + CACNA1H |
| Short name: |
Anti-CACNA1G + CACNA1H (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, T classification, a 1G subunit and CACNA1H (polyclonal), voltage-dependent, antibody to-calcium channel |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CACNA1G and IDBG-58847 and ENSG00000006283 and 8913, CACNA1G and IDBG-638512 and ENSBTAG00000009835 and 282411, Ca(V)T, Cacna1g and IDBG-208893 and ENSMUSG00000020866 and 12291, Plasma membranes, T type, alpha 1G subunit, scaffold protein binding, this GO :0001508 and action potential and biological process this GO :0002027 and regulation of heart rate and biological process this GO :0005216 and ion channel activity and molecular function this GO :0005244 and voltage-gated ion channel activity and molecular function this GO :0005245 and voltage-gated calcium channel activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005891 and voltage-gated calcium channel complex and cellular component this GO :0006810 and transport and biological process this GO :0006811 and ion transport and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007411 and axon guidance and biological process this GO :0008332 and low voltage-gated calcium channel activity and molecular function this GO :0010045 and response to nickel cation and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0034220 and ion transmembrane transport and biological process this GO :0034765 and regulation of ion transmembrane transport and biological process this GO :0042391 and regulation of membrane potential and biological process this GO :0045956 and positive regulation of calcium ion-dependent exocytosis and biological process this GO :0055085 and transmembrane transport and biological process this GO :0060371 and regulation of atrial cardiac muscle cell membrane depolarization and biological process this GO :0070509 and calcium ion import and biological process this GO :0086010 and membrane depolarization during action potential and biological process this GO :0097110 and scaffold protein binding and molecular function, this GO :0005216 : ion channel activity, this GO :0005216 : ion channel activity and also this GO :0005244 : voltage-gated ion channel activity and also this GO :0005245 : voltage-gated calcium channel activity and also this GO :0005515 : protein binding and also this GO :0008332 : low voltage-gated calcium channel activity and also this GO :0097110 : scaffold protein binding, this GO :0005244 : voltage-gated ion channel activity, this GO :0005245 : voltage-gated calcium channel activity, this GO :0005515 : protein binding, this GO :0008332 : low voltage-gated calcium channel activity, this GO :0097110 : scaffold protein binding, voltage-dependent, 1 and Cav3, 1 and NBR13, calcium channel |
| Identity: |
1395 |
| Gene: |
CACNA1H |
More about : CACNA1H |
| Long gene name: |
calcium voltage-gated channel subunit alpha1 H |
| Synonyms gene name: |
T type, alpha 1H subunit , calcium channel, voltage-dependent |
| Locus: |
16p13, 3 |
| Discovery year: |
1999-01-08 |
| GenBank acession: |
AL031703 |
| Entrez gene record: |
8912 |
| Pubmed identfication: |
9670923 16382099 |
| RefSeq identity: |
NM_001005407 |
| Classification: |
Calcium voltage-gated channel subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000172992 |