| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ABCD4 |
| Specificity: |
This antibody reacts specifically with ABCD4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ABCD4 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol, ABCD1 localizes to peroxisomes, ABCD1-4 that are known to be present in the human peroxisome membrane, ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors, All four proteins are ABC half-transporters, PMP22 and ABCD3, The peroxisomal membrane comprises two quantitatively major proteins, a peroxisomal disorder which affects lipid storage, which are adversely affected in X-ALD, which dimerize to form an active transporter, The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PMP69 P70R EST352188 |
| Also known as: |
ABCD4 Polyclonal Antibody |
| Other name: |
Anti-ABCD4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ABCD4 |
| Short name: |
Anti-ABCD4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, member 4 (polyclonal), sub-family D (ALD), antibody to-adenosine triphosphate-binding cassette |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ABC41 and EST352188 and MAHCJ and P70R and P79R and PMP69 and PXMP1L, ABCD4 and IDBG-11957 and ENSG00000119688 and 5826, ABCD4 and IDBG-646851 and ENSBTAG00000014633 and 528646, ATPase activity, Abcd4 and IDBG-156897 and ENSMUSG00000021240 and 19300, Plasma membranes, coupled to transmembrane movement of substances, coupled to transmembrane movement of substances, coupled to transmembrane movement of substances and molecular function this GO :0043190 and ATP-binding cassette (ABC) transporter complex and cellular component this GO :0055085 and transmembrane transport and biological process, member 4, sub-family D (ALD), this GO :0005524 and ATP binding and molecular function this GO :0005777 and peroxisome and cellular component this GO :0005778 and peroxisomal membrane and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006810 and transport and biological process this GO :0009235 and cobalamin metabolic process and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016887 and ATPase activity and molecular function this GO :0042626 and ATPase activity, this GO :0005524 : ATP binding, this GO :0005524 : ATP binding and also this GO :0016887 : ATPase activity and also this GO :0042626 : ATPase activity, this GO :0016887 : ATPase activity, this GO :0042626 : ATPase activity, ATP-binding cassette |
| Identity: |
68 |
| Gene: |
ABCD4 |
More about : ABCD4 |
| Long gene name: |
ATP binding cassette subfamily D member 4 |
| Synonyms gene: |
PXMP1L |
| Synonyms gene name: |
ATP-binding cassette, member 4 , sub-family D (ALD) |
| Locus: |
14q24, 3 |
| Discovery year: |
1997-10-27 |
| GenBank acession: |
AF009746 |
| Entrez gene record: |
5826 |
| Pubmed identfication: |
9266848 9302272 |
| RefSeq identity: |
NM_005050 |
| Classification: |
ATP binding cassette subfamily D |
| Havana BLAST/BLAT: |
OTTHUMG00000171207 |