| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
NELL2/NRP2 |
| Specificity: |
This antibody reacts specifically with NELL2/NRP2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human NELL2/NRP2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Due to alternative splicing, NELL2 exists as a homotrimer associated with the endoplasmic reticulum (ER) and is specifically expressed in neurons playing a role in calcium-dependent intracellular events, NELL2 may act as a trophic factor in addition to its role as a signaling molecule implicated in the regulation of cell growth and differentiation, The additional isoform is therefore retained in the cytosol and functions as a non-secreted cytoplasmic protein that interacts with PKC bI, an additional NELL2 isoform exists that is identical to full length NELL2 except that it lacks the signal peptide that directs secretion, five VWFC (von Willebrand factor C) domains and six EGF-like repeats that participate in calcium binding, NELL2 is a secreted glycoprotein with one N-terminal TSP-like domain |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
NRP2 |
| Also known as: |
NELL2/NRP2 Polyclonal Antibody |
| Other name: |
Anti-NELL2/NRP2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
NELL2/NRP2 |
| Short name: |
Anti-NELL2/NRP2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-NEL-like 2 (chicken)/neuropilin 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Extracellular, Extracellular, NELL2 and IDBG-28191 and ENSG00000184613 and 4753, NELL2 and IDBG-633287 and ENSBTAG00000032183 and 524622, NP2 and NPN2 and PRO2714 and VEGF165R2, NRP2, NRP2 and IDBG-643390 and ENSBTAG00000011971 and 541004, NRP2 and IDBG-79320 and ENSG00000118257 and 8828, Nell2 and IDBG-177541 and ENSMUSG00000022454 and 54003, Nrp2 and IDBG-160044 and ENSMUSG00000025969 and 18187, metal ion binding, neuropilin 2, protein binding, this GO :0001525 and angiogenesis and biological process this GO :0001755 and neural crest cell migration and biological process this GO :0001764 and neuron migration and biological process this GO :0001938 and positive regulation of endothelial cell proliferation and biological process this GO :0002116 and semaphorin receptor complex and cellular component this GO :0004872 and receptor activity and molecular function this GO :0005021 and vascular endothelial growth factor-activated receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007411 and axon guidance and biological process this GO :0007507 and heart development and biological process this GO :0008201 and heparin binding and molecular function this GO :0010595 and positive regulation of endothelial cell migration and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0017154 and semaphorin receptor activity and molecular function this GO :0019838 and growth factor binding and molecular function this GO :0019955 and cytokine binding and molecular function this GO :0021675 and nerve development and biological process this GO :0021828 and this GO nadotrophin-releasing hormone neuronal migration to the hypothalamus and biological process this GO :0030424 and axon and cellular component this GO :0038084 and vascular endothelial growth factor signaling pathway and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048010 and vascular endothelial growth factor receptor signaling pathway and biological process this GO :0048846 and axon extension involved in axon guidance and biological process this GO :0050919 and negative chemotaxis and biological process this GO :0061549 and sympathetic ganglion development and biological process this GO :0097490 and sympathetic neuron projection extension and biological process this GO :0097491 and sympathetic neuron projection guidance and biological process this GO :1902285 and semaphorin-plexin signaling pathway involved in neuron projection guidance and biological process, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0005021 : vascular endothelial growth factor-activated receptor activity and also this GO :0005515 : protein binding and also this GO :0008201 : heparin binding and also this GO :0017154 : semaphorin receptor activity and also this GO :0019838 : growth factor binding and also this GO :0019955 : cytokine binding and also this GO :0046872 : metal ion binding, this GO :0005021 : vascular endothelial growth factor-activated receptor activity, this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component, this GO :0005509 : calcium ion binding, this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0008201 : heparin binding, this GO :0017154 : semaphorin receptor activity, this GO :0019838 : growth factor binding, this GO :0019955 : cytokine binding, this GO :0046872 : metal ion binding, NEL-like 2 (chicken) |
| Identity: |
7751 |
| Gene: |
NELL2 |
More about : NELL2 |
| Long gene name: |
neural EGFL like 2 |
| Synonyms gene name: |
nel (chicken)-like 2 NEL-like 2 (chicken) |
| Locus: |
12q12 |
| Discovery year: |
1996-07-17 |
| GenBank acession: |
D83018 |
| Entrez gene record: |
4753 |
| Pubmed identfication: |
8975702 25537860 |
| RefSeq identity: |
NM_006159 |
| Havana BLAST/BLAT: |
OTTHUMG00000169464 |