| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CHRDL1 |
| Specificity: |
This antibody reacts specifically with CHRDL1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CHRDL1 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Additionally, CHRDL1 (Chordin-like protein 1), CHRDL1 binds to BMP-4 and prevents the interaction of BMP-4 with its target receptors, CHRDL1 is thought to play a role in dorsoventral axis formation, Chordin is a key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like BMPs and sequestering them in latent complexes, Functioning in a similar manner to chordin, VOPT (Ventroptin) or NRLN1 (Neuralin-1), Wnt proteins and BMPs (bone morphogenetic proteins), also known as CHL, as well as in the differentiation of neural stem cells, embryonic bone formation and angiogenesis, including Shh (sonic hedgehog homolog), is a 450 amino acid secreted protein that contains three VWFC domains, namely chordin and Noggin, thereby antagonizing BMP-4 activity, with their antagonists, The patterning of the central nervous system (CNS) relies on the interaction of multiple signaling molecules |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
NRLN1 CHL |
| Also known as: |
CHRDL1 Polyclonal Antibody |
| Other name: |
Anti-CHRDL1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CHRDL1 |
| Short name: |
Anti-CHRDL1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CHRDL1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
29861 |
| Gene: |
CHRDL1 |
More about : CHRDL1 |
| Long gene name: |
chordin like 1 |
| Synonyms gene: |
MGC1 |
| Synonyms gene name: |
megalocornea 1 (X-linked) |
| Locus: |
Xq23 |
| Discovery year: |
2004-01-28 |
| GenBank acession: |
AL049176 |
| Entrez gene record: |
91851 |
| Pubmed identfication: |
11441185 11118896 22284829 |
| RefSeq identity: |
NM_145234 |
| Havana BLAST/BLAT: |
OTTHUMG00000022199 |
| Locus Specific Databases: |
Mental Retardation database |