| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
KCNQ2 |
| Specificity: |
This antibody reacts specifically with KCNQ2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human KCNQ2 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Benign familial neonatal convulsions (BFNC), Both proteins display a broad distribution within the brain, Epilepsy results from an electrical hyperexcitability in the central nervous system, KCNQ2 and KCNQ3 are voltage-gated potassium channel proteins with six putative transmembrane domains, Potassium channels are important regulators of electrical signaling, an autosomal dominant epilepsy of infancy, determining the firing properties and responsiveness of a variety of neurons, has been shown to be caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes, with expression patterns that largely overlap, &euro, &trade, 5% of the worldâ, Epilepsy affects about 0, s population and has a large genetic component |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Kv7, 2 ENB1 BFNC KCNA11 HNSPC |
| Also known as: |
KCNQ2 Polyclonal Antibody |
| Other name: |
Anti-KCNQ2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
KCNQ2 |
| Short name: |
Anti-KCNQ2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-KCNQ2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
6296 |
| Gene: |
KCNQ2 |
More about : KCNQ2 |
| Long gene name: |
potassium voltage-gated channel subfamily Q member 2 |
| Synonyms gene: |
EBN EBN1 |
| Synonyms gene name: |
KQT-like subfamily, member 2 , member 2 potassium channel, potassium voltage-gated channel, voltage gated KQT-like subfamily Q |
| Locus: |
20q13, 33 |
| Discovery year: |
1998-01-12 |
| GenBank acession: |
AF033348 |
| Entrez gene record: |
3785 |
| Pubmed identfication: |
9425895 16382104 |
| RefSeq identity: |
NM_172109 |
| Classification: |
Potassium voltage-gated channels |
| Havana BLAST/BLAT: |
OTTHUMG00000033049 |