| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Humanin |
| Specificity: |
This antibody reacts specifically with Humanin |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Humanin |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Humanin acts as a ligand for formyl peptide receptor-like 1 (FPRL1) with APP and utilizes its neuroprotective effects by inhibiting FPRL1 access to APP, Humanin expression levels may be dependent on defects in energy production in muscles with mitochondrial abnormalities, Humanin is mainly expressed in the kidney, Humanin protects neuronal cells from damage caused by Alzheimer's disease genes, The peptide has been detected in muscles of patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO), The peptide prevents Bax translocation from cytosol to mitochondria, The secreted protein is a neuroprotective factor against death induced by several different types of Alzheimer's disease genes, an endogenous anti-apoptotic peptide against Alzheimer disease-related insults, consists of 24 amino acids, heart, liver, specifically APP (amyloid precursor protein), testis and skeletal muscles, Humanin |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HN 16S |
| Also known as: |
Humanin Polyclonal Antibody |
| Other name: |
Anti-Humanin Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Humanin |
| Short name: |
Anti-Humanin (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Humanin (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
7471 |
| Gene: |
MT-RNR2 |
More about : MT-RNR2 |
| Long gene name: |
mitochondrially encoded 16S RNA |
| Synonyms gene: |
MTRNR2 |
| Synonyms name: |
humanin formyl-humanin |
| Locus: |
mitochondria |
| Discovery year: |
1989-10-12 |
| Entrez gene record: |
4550 |
| Pubmed identfication: |
12009529 12445508 |
| RefSeq identity: |
NC_012920 |
| Classification: |
Endogenous ligands Mitochondrially encoded ribosomal RNAs |