| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
WBP2 |
| Specificity: |
This antibody reacts specifically with WBP2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human WBP2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
The WW domain is composed of 38 to 40 semi-conserved amino acids and is shared by various groups of proteins, The domain mediates protein-protein interactions through the binding of polyproline ligands, The gene encoding WBP2 is located on human chromosome 17, WBP2 binds to the WW domain of Yes-associated protein (YAP), WW domain containing E3 ubiquitin protein ligase 1 (AIP5) and WW domain containing E3 ubiquitin protein ligase 2 (AIP2), colon, early onset breast cancer and a predisposition to cancers of the ovary, including structural, prostate gland and fallopian tubes, regulatory and signaling proteins, some of which are involved in tumor suppression and in the pathogenesis of Li-Fraumeni syndrome, which comprises over 2, 200 genes, 5% of the human genome and encodes over 1, WW domain-binding protein 2 (WBP2) is a 261 amino acid protein expressed in most tissues |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
WBP-2 GRAMD6 |
| Also known as: |
WBP2 Polyclonal Antibody |
| Other name: |
Anti-WBP2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
WBP2 |
| Short name: |
Anti-WBP2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-WBP2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
12738 |
| Gene: |
WBP2 |
More about : WBP2 |
| Long gene name: |
WW domain binding protein 2 |
| Locus: |
17q25, 1 |
| Discovery year: |
1999-11-26 |
| GenBank acession: |
U79458 |
| Entrez gene record: |
23558 |
| Pubmed identfication: |
7644498 26881968 23233354 |
| RefSeq identity: |
NM_012478 |
| Classification: |
GRAM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000179896 |