| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CCKAR |
| Specificity: |
This antibody reacts specifically with CCKAR |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CCKAR |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A (CCKAR)and B (CCKBR), CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion, Class A receptors have also been described in the anterior pituitary, Further, It appears to play a role in slowing gastric emptying, Parkinson disease, These appear to be mediated through 2 general classes of receptors, Through binding to class A receptors, and drug addiction, and potentiation of insulin secretion, and regions of the central nervous system, based on their binding affinities for CCK/gastrin family peptides, it has been implicated as a mediator of pancreatic growth and tumorigenesis, myenteric plexus, relaxation of the sphincter of Oddi, schizophrenia, where they have been implicated in the pathogenesis of feeding disorders, The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
CCKAR Polyclonal Antibody |
| Other name: |
Anti-CCKAR Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CCKAR |
| Short name: |
Anti-CCKAR (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-cholecystokinin A receptor (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CCK-A and CCK1-R and CCK1R and CCKRA, CCKAR and IDBG-12723 and ENSG00000163394 and 886, CCKAR and IDBG-641476 and ENSBTAG00000004988 and 506207, Cckar and IDBG-164710 and ENSMUSG00000029193 and 12425, Plasma membranes, cholecystokinin receptor activity, this GO :0001764 and neuron migration and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004951 and cholecystokinin receptor activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007200 and phospholipase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007409 and axonogenesis and biological process this GO :0007584 and response to nutrient and biological process this GO :0007586 and digestion and biological process this GO :0007631 and feeding behavior and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0030900 and forebrain development and biological process this GO :0038188 and cholecystokinin signaling pathway and biological process, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0004951 : cholecystokinin receptor activity, this GO :0004951 : cholecystokinin receptor activity, cholecystokinin A receptor |
| Identity: |
1570 |
| Gene: |
CCKAR |
More about : CCKAR |
| Long gene name: |
cholecystokinin A receptor |
| Locus: |
4p15, 2 |
| Discovery year: |
1993-07-13 |
| GenBank acession: |
L19315 |
| Entrez gene record: |
886 |
| Classification: |
Cholecystokinin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000128567 |