| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Unc5a/UNC5H1 |
| Specificity: |
This antibody reacts specifically with Unc5a/UNC5H1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Unc5a |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Additionally, In the absence of netrin-1, The expression of UNC5H receptors is downregulated in multiple carcinomas, This activity is blocked by the binding of netrin-1, Three isoforms of UNC5H1 exist due to alternative splicing events, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H1, also known as UNC5HA (unc-5 homolog A), breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, including colorectal, is a member of the UNC5H family of proteins and is localized to the cell membrane, lung and kidney cancers, ovary, stomach, uterus, when cleaved by a caspase to produce an intracellular fragment containing a death domain, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells, UNC5H receptors induce apoptosis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA1976 UNC5H1 |
| Also known as: |
Unc5a/UNC5H1 Polyclonal Antibody |
| Other name: |
Anti-Unc5a/UNC5H1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Unc5a/UNC5H1 |
| Short name: |
Anti-Unc5a/UNC5H1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, elegans)/UNC5H1 (polyclonal), antibody to-unc-5 homolog A (C |
| Alternative technique: |
polyclonals |
| Identity: |
12567 |
| Gene: |
UNC5A |
More about : UNC5A |
| Long gene name: |
unc-5 netrin receptor A |
| Synonyms gene name: |
elegans) , unc5 (C, elegans homolog) a unc-5 homolog A (C |
| Locus: |
5q35, 2 |
| Discovery year: |
1998-12-09 |
| GenBank acession: |
AB075856 |
| Entrez gene record: |
90249 |
| Pubmed identfication: |
12655055 20372800 |
| RefSeq identity: |
XM_030300 |
| Classification: |
I-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000163225 |