| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CASK/CAMGUK |
| Specificity: |
This antibody reacts specifically with CASK/CAMGUK |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CASK |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CASK (also designated LIN-2) belongs to a MAGUK subfamily which is characterized by a novel domain structure that consists of a calcium/calmodulin- dependent protein kinase domain followed by PDZ, CASK displays a transcription regulation function, CASK is expressed in rat brain where it binds to cell-surface proteins, CASK translocates to the nucleus and interacts with Tbr-1 to form a complex, SH3 and guanylate kinase-like (GUK) domains, and induces the expression of specific genes, and is thought to be involved in signaling at neuronal synapses, and signaling, including Reelin, such as neurexin and syndecan, tumor suppression, which appears crucial for cerebrocortical development, which binds to a specific DNA sequence (the T-element), The MAGUK (membrane-associated guanylate kinase homologs) family of proteins contain multiple protein-binding domains and are involved in cell junction organization |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
LIN2 CAGH39 FGS4 |
| Also known as: |
CASK/CAMGUK Polyclonal Antibody |
| Other name: |
Anti-CASK/CAMGUK Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CASK/CAMGUK |
| Short name: |
Anti-CASK/CAMGUK (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-calcium/calmodulin-dependent serine protein kinase (MAGUK family)/CAMGUK (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CAGH39 and CAMGUK and CMG and FGS4 and LIN2 and MICPCH and MRXSNA and TNRC8, CASK and IDBG-57627 and ENSG00000147044 and 8573, CASK and IDBG-637908 and ENSBTAG00000020136 and 404149, Cask and IDBG-133241 and ENSMUSG00000031012 and 12361, nuclei, this GO :0001953 and negative regulation of cell-matrix adhesion and biological process this GO :0004385 and guanylate kinase activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005516 and calmodulin binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005604 and basement membrane and cellular component this GO :0005634 and nucleus and cellular component this GO :0005652 and nuclear lamina and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007155 and cell adhesion and biological process this GO :0010839 and negative regulation of keratinocyte proliferation and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016020 and membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016363 and nuclear matrix and cellular component this GO :0016772 and transferase activity, this GO :0004385 : guanylate kinase activity, this GO :0004385 : guanylate kinase activity and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005516 : calmodulin binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005516 : calmodulin binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0042043 : neurexin family protein binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042043 : neurexin family protein binding, transferring phosphorus-containing groups and molecular function this GO :0030198 and extracellular matrix organization and biological process this GO :0042043 and neurexin family protein binding and molecular function this GO :0042734 and presynaptic membrane and cellular component this GO :0045202 and synapse and cellular component this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046939 and nucleotide phosphorylation and biological process this GO :0060170 and ciliary membrane and cellular component this GO :0061045 and negative regulation of wound healing and biological process this GO :0070509 and calcium ion import and biological process this GO :0090280 and positive regulation of calcium ion import and biological process this GO :0090288 and negative regulation of cellular response to growth factor stimulus and biological process, calcium/calmodulin-dependent serine protein kinase (MAGUK family) |
| Identity: |
1497 |
| Gene: |
CASK |
More about : CASK |
| Long gene name: |
calcium/calmodulin dependent serine protein kinase |
| Synonyms gene: |
TNRC8 |
| Synonyms gene name: |
trinucleotide repeat containing 8 calcium/calmodulin-dependent serine protein kinase (MAGUK family) |
| Locus: |
Xp11, 4 |
| Discovery year: |
1998-09-25 |
| GenBank acession: |
AF035582 |
| Entrez gene record: |
8573 |
| Pubmed identfication: |
9722958 |
| RefSeq identity: |
NM_003688 |
| Classification: |
Trinucleotide repeat containing Membrane associated guanylate kinases PDZ domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000021378 |
| Locus Specific Databases: |
Mental Retardation database |