| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ABCA7 |
| Specificity: |
This antibody reacts specifically with ABCA7 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ABCA7 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ABCA7, Eukaryotic ABC transporters are largely responsible for trafficking hydrophobic compounds either within the cell as part of a metabolic process, Full-length type I ABCA7 has shown plasma membrane localization, High expression levels of ABCA7 have been reported in myelolymphatic tissues, The cholesterol-responsive transporter, This expression pattern of the two alternatively-spliced isoforms also indicates an involvement in lipid homeostasis in cells of the immune system, maps to human chromosome 19 and mouse chromosome 10 and has been reported as a candidate regulator of ceramide transport in epidermal lipid reorganization, or for secretion from the body, outside the cell for transport to other organs, peripheral leukocytes, reticuloendothelial cells, spleen and bone marrow, though the complete role of ABCA7 is not yet known, thymus, while the type II splicing variant has shown expression predominantly in the endoplasmic reticulum, ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of widely-expressed proteins that use ATP hydrolysis to catalyze the transport of various molecules across extracellular and intracellular membranes |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ABCX |
| Also known as: |
ABCA7 Polyclonal Antibody |
| Other name: |
Anti-ABCA7 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ABCA7 |
| Short name: |
Anti-ABCA7 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, member 7 (polyclonal), sub-family A (ABC1), antibody to-adenosine triphosphate-binding cassette |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ABCA-SSN and ABCX, ABCA7 and IDBG-13665 and ENSG00000064687 and 10347, ABCA7 and IDBG-645574 and ENSBTAG00000020766 and 511762, Abca7 and IDBG-171979 and ENSMUSG00000035722 and 27403, Cell surfaces, apolipoprotein A-I receptor activity, member 7, sub-family A (ABC1), this GO :0000139 and this GO lgi membrane and cellular component this GO :0001891 and pha this GO cytic cup and cellular component this GO :0005215 and transporter activity and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005548 and phospholipid transporter activity and molecular function this GO :0005622 and intracellular and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006909 and pha this GO cytosis and biological process this GO :0007613 and memory and biological process this GO :0009986 and cell surface and cellular component this GO :0010008 and endosome membrane and cellular component this GO :0010875 and positive regulation of cholesterol efflux and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0016887 and ATPase activity and molecular function this GO :0017121 and phospholipid scrambling and biological process this GO :0018149 and peptide cross-linking and biological process this GO :0032587 and ruffle membrane and cellular component this GO :0032780 and negative regulation of ATPase activity and biological process this GO :0032781 and positive regulation of ATPase activity and biological process this GO :0033344 and cholesterol efflux and biological process this GO :0033700 and phospholipid efflux and biological process this GO :0034188 and apolipoprotein A-I receptor activity and molecular function this GO :0034380 and high-density lipoprotein particle assembly and biological process this GO :0034504 and protein localization to nucleus and biological process this GO :0038027 and apolipoprotein A-I-mediated signaling pathway and biological process this GO :0042985 and negative regulation of amyloid precursor protein biosynthetic process and biological process this GO :0043190 and ATP-binding cassette (ABC) transporter complex and cellular component this GO :0050766 and positive regulation of pha this GO cytosis and biological process this GO :0055085 and transmembrane transport and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :1900223 and positive regulation of beta-amyloid clearance and biological process this GO :1901076 and positive regulation of engulfment of apoptotic cell and biological process this GO :1902430 and negative regulation of beta-amyloid formation and biological process this GO :1902995 and positive regulation of phospholipid efflux and biological process, this GO :0005215 : transporter activity, this GO :0005215 : transporter activity and also this GO :0005524 : ATP binding and also this GO :0005548 : phospholipid transporter activity and also this GO :0016887 : ATPase activity and also this GO :0034188 : apolipoprotein A-I receptor activity, this GO :0005524 : ATP binding, this GO :0005548 : phospholipid transporter activity, this GO :0016887 : ATPase activity, this GO :0034188 : apolipoprotein A-I receptor activity, ATP-binding cassette |
| Identity: |
37 |
| Gene: |
ABCA7 |
More about : ABCA7 |
| Long gene name: |
ATP binding cassette subfamily A member 7 |
| Synonyms gene name: |
ATP-binding cassette, member 7 , sub-family A (ABC1) |
| Locus: |
19p13, 3 |
| Discovery year: |
1999-06-11 |
| GenBank acession: |
AF328787 |
| Entrez gene record: |
10347 |
| RefSeq identity: |
NM_019112 |
| Classification: |
ATP binding cassette subfamily A |
| Havana BLAST/BLAT: |
OTTHUMG00000167547 |