| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Neurexin 2 |
| Specificity: |
This antibody reacts specifically with Neurexin 2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Neurexin 2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Caspr (for Contactin-Associated Protein 1, Caspr and the closely related Caspr2, Caspr exists at the paranodal junctions, Caspr may play a role in the communication of glial cells and neurons during development, Neurexins, Neurexins I-III are expressed as a and b isoforms, Sex hormone-binding)-domains separated by EGF domains, Specifically, The a isoforms are made of three cassettes, The a isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin a-latrotoxin, The b isoforms have only one LNS-domain, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), also designated Paranodin in mouse), and binds to the surface glycoprotein Contactin, and play a role in the formation and remodeling of synapes, bind to neuroligins, contains an extracellular domain similar to the other three neurexins, demarcate distinct subdomains in myelinated axons, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal, neurexin II (NRXN2), neurexin III (NRXN3) and Caspr (neurexin IV), which contain two LNS (Laminin A, which include neurexin I (NRXN1), while Caspr2 colocalizes with Shaker-like K+ channels in the juxtaparanodal region, Neurexins comprise a family of neuronal cell surface proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
Neurexin 2 Polyclonal Antibody |
| Other name: |
Anti-Neurexin 2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Neurexin 2 |
| Short name: |
Anti-Neurexin 2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Neurexin 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
8009 |
| Gene: |
NRXN2 |
More about : NRXN2 |
| Long gene name: |
neurexin 2 |
| Synonyms name: |
neurexin II |
| Locus: |
11q13, 1 |
| Discovery year: |
1998-10-14 |
| Entrez gene record: |
9379 |
| Pubmed identfication: |
1621094 |
| RefSeq identity: |
NM_015080 |
| Havana BLAST/BLAT: |
OTTHUMG00000045214 |