| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CCR2 |
| Specificity: |
This antibody reacts specifically with CCR2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from mouse CCR-2 |
| Gene ID: |
729230 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Mar 2009], Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors, The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase, This gene is located in the chemokine receptor gene cluster region, Two alternatively spliced transcript variants are expressed by the gene, [provided by RefSeq, a chemokine which specifically mediates monocyte chemotaxis, This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CC-CKR-2 CKR2 MCP-1-R CD192 FLJ78302 |
| Also known as: |
CCR2 Polyclonal Antibody |
| Other name: |
Anti-CCR2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CCR2 |
| Short name: |
Anti-CCR2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-chemokine (C-C motif) receptor 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BT, CCR2 and IDBG-30182 and ENSG00000121807 and 729230, Plasma membranes, alpha-beta T cell extravasation and biological process this GO :2000464 and positive regulation of astrocyte chemotaxis and biological process this GO :2000473 and positive regulation of hematopoietic stem cell migration and biological process, protein homodimerization activity, this GO :0001974 and blood vessel remodeling and biological process this GO :0002407 and dendritic cell chemotaxis and biological process this GO :0002827 and positive regulation of T-helper 1 type immune response and biological process this GO :0002829 and negative regulation of type 2 immune response and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006874 and cellular calcium ion homeostasis and biological process this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0006955 and immune response and biological process this GO :0006968 and cellular defense response and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007194 and negative regulation of adenylate cyclase activity and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0009611 and response to wounding and biological process this GO :0010574 and regulation of vascular endothelial growth factor production and biological process this GO :0010820 and positive regulation of T cell chemotaxis and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016493 and C-C chemokine receptor activity and molecular function this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019725 and cellular homeostasis and biological process this GO :0030425 and dendrite and cellular component this GO :0031727 and CCR2 chemokine receptor binding and molecular function this GO :0032729 and positive regulation of interferon-gamma production and biological process this GO :0032743 and positive regulation of interleukin-2 production and biological process this GO :0035705 and T-helper 17 cell chemotaxis and biological process this GO :0042535 and positive regulation of tumor necrosis factor biosynthetic process and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0043204 and perikaryon and cellular component this GO :0043310 and negative regulation of eosinophil degranulation and biological process this GO :0045087 and innate immune response and biological process this GO :0046641 and positive regulation of alpha-beta T cell proliferation and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050729 and positive regulation of inflammatory response and biological process this GO :0050870 and positive regulation of T cell activation and biological process this GO :0070098 and chemokine-mediated signaling pathway and biological process this GO :0090026 and positive regulation of monocyte chemotaxis and biological process this GO :0090265 and positive regulation of immune complex clearance by monocytes and macrophages and biological process this GO :2000439 and positive regulation of monocyte extravasation and biological process this GO :2000451 and positive regulation of CD8-positive, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0004950 : chemokine receptor activity and also this GO :0016493 : C-C chemokine receptor activity and also this GO :0031727 : CCR2 chemokine receptor binding and also this GO :0042803 : protein homodimerization activity, this GO :0004950 : chemokine receptor activity, this GO :0016493 : C-C chemokine receptor activity, this GO :0031727 : CCR2 chemokine receptor binding, this GO :0042803 : protein homodimerization activity, 63814 and IDBG-647810 and ENSBTAG00000013586 and 539002, chemokine (C-C motif) receptor 2 |
| Identity: |
1603 |
| Gene: |
CCR2 |
More about : CCR2 |
| Long gene name: |
C-C motif chemokine receptor 2 |
| Synonyms gene: |
CMKBR2 |
| Synonyms gene name: |
chemokine (C-C motif) receptor 2 |
| Locus: |
3p21, 31 |
| Discovery year: |
1995-05-30 |
| Entrez gene record: |
729230 |
| Pubmed identfication: |
8146186 |
| RefSeq identity: |
NM_000647 |
| Classification: |
CD molecules C-C motif chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000156466 |