| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
KRAS |
| Specificity: |
This antibody reacts specifically with KRAS |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cell membrane, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human K-ras |
| Gene ID: |
3845 |
| Swiss Prot: |
P01116 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838), Ras proteins bind GDP/GTP and possess intrinsic GTPase activity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KRAS1 |
| Also known as: |
KRAS Polyclonal Antibody |
| Other name: |
Anti-KRAS Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
KRAS |
| Short name: |
Anti-KRAS (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
C-K-RAS and CFC2 and K-RAS2A and K-RAS2B and K-RAS4A and K-RAS4B and KI-RAS and KRAS1 and KRAS2 and NS and NS3 and RASK2, GABAergic and biological process this GO :0032403 and protein complex binding and molecular function this GO :0035022 and positive regulation of Rac protein signal transduction and biological process this GO :0035176 and social behavior and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045596 and negative regulation of cell differentiation and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048169 and regulation of long-term neuronal synaptic plasticity and biological process this GO :0050900 and leukocyte migration and biological process this GO :0051000 and positive regulation of nitric-oxide synthase activity and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051146 and striated muscle cell differentiation and biological process this GO :0051384 and response to glucocorticoid and biological process this GO :0051385 and response to mineralocorticoid and biological process this GO :0060441 and epithelial tube branching involved in lung morphogenesis and biological process, KRAS and IDBG-23889 and ENSG00000133703 and 3845, KRAS and IDBG-638783 and ENSBTAG00000009778 and 541140, Kras and IDBG-197719 and ENSMUSG00000030265 and 16653, Plasma membranes, protein complex binding, this GO :0000165 and MAPK cascade and biological process this GO :0000186 and activation of MAPKK activity and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0003924 and GTPase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006184 and GTP catabolic process and biological process this GO :0006886 and intracellular protein transport and biological process this GO :0006913 and nucleocytoplasmic transport and biological process this GO :0007165 and signal transduction and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008542 and visual learning and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0015031 and protein transport and biological process this GO :0016020 and membrane and cellular component this GO :0019002 and GMP binding and molecular function this GO :0019003 and GDP binding and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030275 and LRR domain binding and molecular function this GO :0032228 and regulation of synaptic transmission, this GO :0003924 : GTPase activity, this GO :0003924 : GTPase activity and also this GO :0005515 : protein binding and also this GO :0005525 : GTP binding and also this GO :0019002 : GMP binding and also this GO :0019003 : GDP binding and also this GO :0030275 : LRR domain binding and also this GO :0032403 : protein complex binding, this GO :0005515 : protein binding, this GO :0005525 : GTP binding, this GO :0019002 : GMP binding, this GO :0019003 : GDP binding, this GO :0030275 : LRR domain binding, this GO :0032403 : protein complex binding, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog |
| Identity: |
6407 |
| Gene: |
KRAS |
More about : KRAS |
| Long gene name: |
GTPase , KRAS proto-oncogene |
| Synonyms gene: |
KRAS2 |
| Synonyms gene name: |
v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog Kirsten rat sarcoma viral oncogene homolog |
| Locus: |
12p12, 1 |
| Discovery year: |
1988-06-02 |
| GenBank acession: |
BC010502 |
| Entrez gene record: |
3845 |
| RefSeq identity: |
NM_033360 |
| Classification: |
RAS type GTPase family |
| Havana BLAST/BLAT: |
OTTHUMG00000171193 |
| Locus Specific Databases: |
LRG_344 |