| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Doublecortin / DBCN / DCX |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the DCX antibody should be determined by the researcher |
| Added buffer: |
025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2 |
| Intented use: |
This antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O43602 |
| Purity: |
Antigen affinity |
| Description: |
In addition, In the developing cortex, Multiple transcript variants encoding different isoforms have been found for this gene, Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules, The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, This gene encodes a member of the doublecortin family, also known as Doublin or Lissencephalin-X, and this interaction is important to proper microtubule function in the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation, is a protein that in humans is encoded by the DCX gene, leading to epilepsy, mental retardation, subcortical band heterotopia (double cortex syndrome) in females and lissencephaly (smooth brain syndrome) in males, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, which bind microtubules, Neuronal migration protein Doublecortin |
| Immunogen: |
Amino acids 74-100 (QSLRFHQNMELDFGHFDERDKTSRNMR-human) were used as the immunogen for the DCX antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the DCX antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Doublecortin / DBCN / DCX |
| Short name: |
Doublecortin Antibody / DBCN / DCX |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Doublecortin (Antibody to) / DBCN / DCX |
| Alternative technique: |
antibodies |
| Identity: |
2714 |
| Gene: |
DCX |
More about : DCX |
| Long gene name: |
doublecortin |
| Synonyms gene name: |
X-linked (doublecortin) , doublecortex, lissencephaly |
| Synonyms: |
SCLH DC LISX DBCN XLIS |
| Synonyms name: |
doublecortex |
| Locus: |
Xq23 |
| Discovery year: |
1998-03-24 |
| GenBank acession: |
AF040254 |
| Entrez gene record: |
1641 |
| Pubmed identfication: |
9489699 9489700 |
| RefSeq identity: |
NM_178153 |
| Classification: |
Doublecortin superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000022204 |