| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Fibrinogen alpha chain (FGA) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the Fibrinogen alpha chain antibody should be determined by the researcher |
| Added buffer: |
025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2 |
| Intented use: |
This Fibrinogen alpha chain antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P02671 |
| Purity: |
Antigen affinity |
| Description: |
Alternative splicing results in multiple transcript variants, Following vascular injury, Mutations in this gene lead to several disorders, This gene encodes the alpha subunit of the coagulation factor fibrinogen, afibrinogenemia and renal amyloidosis, at least one of which encodes an isoform that undergoes proteolytic processing, hypofibrinogenemia, including dysfibrinogenemia, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin, which is a component of the blood clot, Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene |
| Immunogen: |
This sequence is specific to the alpha-E isoform and not found in the alpha isoform, Amino acids 687-727 (RTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVE-human) were used as the immunogen for the Fibrinogen alpha chain antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Fibrinogen alpha chain antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
Secreted |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Fibrinogen alpha chain (FGA) |
| Short name: |
Fibrinogen alpha chain Antibody (FGA) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Fibrinogen a epitope (Antibody to) (fibrinogen alpha chain) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, FGA and IDBG-42099 and ENSG00000171560 and 2243, FGA and IDBG-628958 and ENSBTAG00000001638 and 522039, Fga and IDBG-154534 and ENSMUSG00000028001 and 14161, Fib2, bridging, bridging and also this GO :0050839 : cell adhesion molecule binding, bridging and molecular function this GO :0031091 and platelet alpha granule and cellular component this GO :0031093 and platelet alpha granule lumen and cellular component this GO :0034116 and positive regulation of heterotypic cell-cell adhesion and biological process this GO :0043623 and cellular protein complex assembly and biological process this GO :0045907 and positive regulation of vasoconstriction and biological process this GO :0045921 and positive regulation of exocytosis and biological process this GO :0050714 and positive regulation of protein secretion and biological process this GO :0050839 and cell adhesion molecule binding and molecular function this GO :0051258 and protein polymerization and biological process this GO :0051592 and response to calcium ion and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0070527 and platelet aggregation and biological process this GO :0072377 and blood coagulation, common pathway and biological process this GO :0072562 and blood microparticle and cellular component this GO :0090277 and positive regulation of peptide hormone secretion and biological process this GO :1900026 and positive regulation of substrate adhesion-dependent cell spreading and biological process this GO :1902042 and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2000261 and negative regulation of blood coagulation, common pathway and biological process this GO :2000352 and negative regulation of endothelial cell apoptotic process and biological process, protein binding, this GO :0002576 and platelet degranulation and biological process this GO :0005102 and receptor binding and molecular function this GO :0005198 and structural molecule activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005577 and fibrinogen complex and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005938 and cell cortex and cellular component this GO :0007160 and cell-matrix adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007596 and blood coagulation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0030168 and platelet activation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030674 and protein binding, this GO :0005102 : receptor binding, this GO :0005102 : receptor binding and also this GO :0005198 : structural molecule activity and also this GO :0005515 : protein binding and also this GO :0030674 : protein binding, this GO :0005198 : structural molecule activity, this GO :0005515 : protein binding, this GO :0030674 : protein binding, this GO :0050839 : cell adhesion molecule binding, fibrinogen alpha chain |
| Identity: |
3661 |
| Gene: |
FGA |
More about : FGA |
| Long gene name: |
fibrinogen alpha chain |
| Synonyms gene name: |
A alpha polypeptide , fibrinogen |
| Locus: |
4q31, 3 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
2243 |
| RefSeq identity: |
NM_000508 |
| Classification: |
Endogenous ligands Fibrinogen C domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000150330 |
| Locus Specific Databases: |
A Database For Human Fibrinogen Variants LRG_557 |