| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
NKG2D |
| Specificity: |
This antibody reacts specifically with NKG2D |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from rat NKG2D |
| Gene ID: |
24934 |
| Swiss Prot: |
O70215 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation, Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins, May play a regulatory role in differentiation and survival of NK cells, Participates in NK cell-mediated bone marrow graft rejection, Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, Signaling involves calcium influx, Stimulates perforin-mediated elimination of ligand-expressing tumor cells, culminating in the expression of TNF-alpha, leading to cytotoxic activity, Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
NKG2D KLR NKG2-D CD314 |
| Also known as: |
NKG2D Polyclonal Antibody |
| Other name: |
Anti-NKG2D Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
NKG2D |
| Short name: |
Anti-NKG2D (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-NKG2D (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
18788 |
| Gene: |
KLRK1 |
More about : KLRK1 |
| Long gene name: |
killer cell lectin like receptor K1 |
| Synonyms gene: |
D12S2489E |
| Synonyms gene name: |
DNA segment on chromosome 12 (unique) 2489 expressed sequence killer cell lectin-like receptor subfamily K, member 1 |
| Locus: |
12p13, 2 |
| Discovery year: |
2003-12-12 |
| GenBank acession: |
AJ001687 |
| Entrez gene record: |
22914 |
| Pubmed identfication: |
9683661 2007850 |
| RefSeq identity: |
NM_007360 |
| Classification: |
Killer cell lectin like receptors CD molecules C-type lectin domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000168574 |