| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
BCR / Breakpoint cluster region protein |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Added buffer: |
025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2 |
| Intented use: |
This BCR antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P11274 |
| Purity: |
Antigen affinity |
| Description: |
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, Although the BCR-ABL fusion protein has been extensively studied, The chromosome 22 breakpoint for this translocation is located within the BCR gene, The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac, The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, Two transcript variants encoding different isoforms have been found for this gene, the function of the normal BCR gene product is not clear, the gene at the chromosome 9 breakpoint, which is often found in patients with chronic myelogenous leukemia, The breakpoint cluster region protein (BCR) is a protein that in humans is encoded by the BCR gene |
| Immunogen: |
Amino acids M1-A100 from the human protein were used as the immunogen for the BCR antibody |
| Storage: |
After reconstitution, Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, store at 4oC, the BCR antibody may be kept for up to one month refrigerated at +4 degrees C, For long-term, Prior to reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
BCR / Breakpoint cluster region protein |
| Short name: |
BCR Antibody / Breakpoint cluster region protein |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
BCR (Antibody to) / Breakpoint cluster region protein |
| Alternative technique: |
antibodies |
| Identity: |
1014 |
| Gene: |
BCR |
More about : BCR |
| Long gene name: |
BCR, RhoGEF and GTPase activating protein |
| Synonyms gene: |
D22S11 BCR1 |
| Synonyms gene name: |
breakpoint cluster region |
| Synonyms: |
D22S662 CML PHL ALL |
| Locus: |
22q11, 23 |
| Discovery year: |
1986-01-01 |
| Entrez gene record: |
613 |
| Pubmed identfication: |
1657398 18070886 |
| RefSeq identity: |
NM_004327 |
| Classification: |
Rho guanine nucleotide exchange factors Pleckstrin homology domain containing C2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000150655 |
| Locus Specific Databases: |
LRG_1112 |