| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
AIRE |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Added buffer: |
025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2 |
| Intented use: |
This AIRE antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O43918 |
| Purity: |
Antigen affinity |
| Description: |
Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED), The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus, This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein, The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene |
| Immunogen: |
Amino acids M1-K120 from the human protein were used as the immunogen for the AIRE antibody |
| Storage: |
After reconstitution, Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, store at 4oC, the AIRE antibody may be kept for up to one month refrigerated at +4 degrees C, For long-term, Prior to reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
AIRE |
| Short name: |
AIRE Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
autoimmune regulator (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AIRE and IDBG-5152 and ENSG00000160224 and 326, AIRE and IDBG-639674 and ENSBTAG00000023393 and, AIRE1 and APECED and APS1 and APSI and PGA1, Aire and IDBG-168233 and ENSMUSG00000000731 and 11634, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006417 and regulation of translation and biological process this GO :0006955 and immune response and biological process this GO :0006959 and humoral immune response and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0042393 and histone binding and molecular function this GO :0042802 and identical protein binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045182 and translation regulator activity and molecular function this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process, nuclei, this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006351 and transcription, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0042393 : histone binding and also this GO :0042802 : identical protein binding and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0045182 : translation regulator activity, this GO :0003682 : chromatin binding, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0042393 : histone binding, this GO :0042802 : identical protein binding, this GO :0044212 : transcription regulatory region DNA binding, this GO :0045182 : translation regulator activity, translation regulator activity, autoimmune regulator |
| Identity: |
360 |
| Gene: |
AIRE |
More about : AIRE |
| Long gene name: |
autoimmune regulator |
| Synonyms gene: |
APECED |
| Synonyms gene name: |
autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) |
| Synonyms: |
PGA1 APS1 |
| Synonyms name: |
autoimmune polyendocrinopathy candidiasis ectodermal dystrophy |
| Locus: |
21q22, 3 |
| Discovery year: |
1997-09-05 |
| GenBank acession: |
AB006684 |
| Entrez gene record: |
326 |
| Pubmed identfication: |
9398840 |
| Classification: |
PHD finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000086921 |
| Locus Specific Databases: |
AIREbase: Mutation registry for APECED LRG_18 |