| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TARDBP |
| Specificity: |
This antibody reacts specifically with TARDBP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TDP-43 |
| Gene ID: |
23435 |
| Swiss Prot: |
Q13148 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat, Involved in the regulation of CFTR splicing, It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon, May also be involved in microRNA biogenesis, Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR, The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis, apoptosis and cell division, DNA and RNA-binding protein which regulates transcription and splicing |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TDP-43 ALS10 |
| Also known as: |
TARDBP Polyclonal Antibody |
| Other name: |
Anti-TARDBP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TARDBP |
| Short name: |
Anti-TARDBP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TARDBP (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
11571 |
| Gene: |
TARDBP |
More about : TARDBP |
| Long gene name: |
TAR DNA binding protein |
| Locus: |
1p36, 22 |
| Discovery year: |
2000-01-28 |
| GenBank acession: |
U23731 |
| Entrez gene record: |
23435 |
| Pubmed identfication: |
7745706 |
| RefSeq identity: |
NM_007375 |
| Classification: |
RNA binding motif containing |
| Havana BLAST/BLAT: |
OTTHUMG00000002120 |
| Locus Specific Databases: |
ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_659 |