| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
MAP3K8 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, IHC (FFPE): 1-2ug/ml, Western blot: 0 |
| Added buffer: |
025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2 |
| Intented use: |
This MAP3K8 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P41279 |
| Purity: |
Antigen affinity |
| Description: |
Additionally, Alternate splicing results in multiple transcript variants that encode the same protein, The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways, The shorter isoform has been shown to display weaker transforming activity, This gene is an oncogene that encodes a member of the serine/threonine protein kinase family, This gene may also utilize a downstream in-frame translation start codon, This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB, and thus produce an isoform containing a shorter N-terminus, this protein was found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation, Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene |
| Immunogen: |
Amino acids D9-L193 were used as the immunogen for the MAP3K8 antibody |
| Storage: |
After reconstitution, Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, store at 4oC, the MAP3K8 antibody may be kept for up to one month refrigerated at +4 degrees C, For long-term, Prior to reconstitution |
| Localization: |
membranous, Cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
MAP3K8 |
| Short name: |
MAP3K8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MAP3K8 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6860 |
| Gene: |
MAP3K8 |
More about : MAP3K8 |
| Long gene name: |
mitogen-activated protein kinase kinase kinase 8 |
| Synonyms gene: |
COT ESTF |
| Synonyms: |
Tpl-2 EST c-COT MEKK8 |
| Locus: |
10p11, 23 |
| Discovery year: |
1992-09-14 |
| GenBank acession: |
D14497 |
| Entrez gene record: |
1326 |
| Pubmed identfication: |
2072910 8479752 |
| RefSeq identity: |
NM_005204 |
| Classification: |
Mitogen-activated protein kinase kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000017889 |