| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TAK1 / MAP3K7 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Added buffer: |
025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2 |
| Intented use: |
This TAK1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O43318 |
| Purity: |
Antigen affinity |
| Description: |
Four alternatively spliced transcript variants encoding distinct isoforms have been reported, In response to IL-1, MAP2K4/MKK4, MAP3K7P1/TAB1 and MAP3K7P2/TAB2, The protein encoded by this gene is a member of the serine/threonine protein kinase family, This kinase can also activate MAPK8/JNK, This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), also known as TAK1, and controls a variety of cell functions including transcription regulation and apoptosis, and thus plays a role in the cell response to environmental stresses, is an enzyme that in humans is encoded by the MAP3K7 gene, this complex is required for the activation of nuclear factor kappa B, this protein forms a kinase complex including TRAF6, Mitogen-activated protein kinase kinase kinase 7 |
| Immunogen: |
Amino acids RLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQ were used as the immunogen for the TAK1 antibody |
| Storage: |
After reconstitution, Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, store at 4oC, the TAK1 antibody may be kept for up to one month refrigerated at +4 degrees C, For long-term, Prior to reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TAK1 / MAP3K7 |
| Short name: |
TAK1 Antibody / MAP3K7 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TAK1 (Antibody to) / mitogen-activated protein phosphorylation catalyst kinase phosphorylation catalyst 7 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0007250 and activation of NF-kappaB-inducing kinase activity and biological process this GO :0007252 and I-kappaB phosphorylation and biological process this GO :0007254 and JNK cascade and biological process this GO :0008385 and IkappaB kinase complex and cellular component this GO :0010008 and endosome membrane and cellular component this GO :0016772 and transferase activity, MAP3K7 and IDBG-632332 and ENSBTAG00000002625 and 529146, MAP3K7 and IDBG-94374 and ENSG00000135341 and 6885, MEKK7 and TAK1 and TGF1a, Map3k7 and IDBG-132962 and ENSMUSG00000028284 and 26409, leucine rich repeat containing receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043507 and positive regulation of JUN kinase activity and biological process this GO :0043966 and histone H3 acetylation and biological process this GO :0045087 and innate immune response and biological process this GO :0046330 and positive regulation of JNK cascade and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050870 and positive regulation of T cell activation and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :0097110 and scaffold protein binding and molecular function this GO :1902443 and negative regulation of ripoptosome assembly involved in necroptotic process and biological process this GO :2000377 and regulation of reactive oxygen species metabolic process and biological process this GO :2001234 and negative regulation of apoptotic signaling pathway and biological process, nuclei, this GO :0000165 and MAPK cascade and biological process this GO :0000186 and activation of MAPKK activity and biological process this GO :0000187 and activation of MAPK activity and biological process this GO :0000287 and magnesium ion binding and molecular function this GO :0001525 and angiogenesis and biological process this GO :0001841 and neural tube formation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002726 and positive regulation of T cell cytokine production and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004708 and MAP kinase kinase activity and molecular function this GO :0004709 and MAP kinase kinase kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005671 and Ada2/Gcn5/Ada3 transcription activator complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006351 and transcription, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004708 : MAP kinase kinase activity and also this GO :0004709 : MAP kinase kinase kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004708 : MAP kinase kinase activity, this GO :0004709 : MAP kinase kinase kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0097110 : scaffold protein binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0097110 : scaffold protein binding, transferring phosphorus-containing groups and molecular function this GO :0032743 and positive regulation of interleukin-2 production and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035872 and nucleotide-binding domain, mitogen-activated protein kinase kinase kinase 7 |
| Identity: |
6859 |
| Gene: |
MAP3K7 |
More about : MAP3K7 |
| Long gene name: |
mitogen-activated protein kinase kinase kinase 7 |
| Synonyms gene: |
TAK1 |
| Synonyms: |
MEKK7 |
| Synonyms name: |
TGF-beta activated kinase 1 |
| Locus: |
6q15 |
| Discovery year: |
1998-05-22 |
| GenBank acession: |
AB009356 |
| Entrez gene record: |
6885 |
| Pubmed identfication: |
9466656 |
| RefSeq identity: |
NM_145331 |
| Classification: |
Mitogen-activated protein kinase kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000015217 |
| Locus Specific Databases: |
The Globin Gene Server |