| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Complement Factor I / CFI |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Intented use: |
This Factor I antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P05156 |
| Purity: |
Antigen affinity |
| Description: |
Defects in this gene cause complement factor I deficiency, Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene, The encoded preproprotein is cleaved to produce both heavy and light chains, This gene encodes a serine proteinase that is essential for regulating the complement cascade, This heterodimer can cleave and inactivate the complement components C4b and C3b, a disease characterized by acute renal failure, also known as C3b/C4b inactivator, an autosomal recessive disease associated with a susceptibility to pyogenic infections, and it prevents the assembly of the C3 and C5 convertase enzymes, is a protein that in humans is encoded by the CFI gene, microangiopathic hemolytic anemia and thrombocytopenia, which are linked by disulfide bonds to form a heterodimeric glycoprotein, Complement factor I |
| Immunogen: |
Amino acids K19-D220 were used as the immunogen for the Factor I antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Factor I antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Complement Factor I / CFI |
| Short name: |
Complement Factor I Antibody / CFI |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Complement Factor I (Antibody to) / complement factor I |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AHUS3 and ARMD13 and C3b-INA and C3BINA and FI and IF and KAF, BT, CFI and IDBG-33966 and ENSG00000205403 and 3426, Cfi and IDBG-193652 and ENSMUSG00000058952 and 12630, classical pathway and biological process this GO :0016020 and membrane and cellular component this GO :0030449 and regulation of complement activation and biological process this GO :0045087 and innate immune response and biological process this GO :0046872 and metal ion binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component, metal ion binding, nuclei, this GO :0003824 and catalytic activity and molecular function this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0005044 and scavenger receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0006508 and proteolysis and biological process this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0006958 and complement activation, this GO :0003824 : catalytic activity, this GO :0003824 : catalytic activity and also this GO :0004252 : serine-type endopeptidase activity and also this GO :0005044 : scavenger receptor activity and also this GO :0005515 : protein binding and also this GO :0046872 : metal ion binding, this GO :0004252 : serine-type endopeptidase activity, this GO :0005044 : scavenger receptor activity, this GO :0005515 : protein binding, this GO :0046872 : metal ion binding, 64790 and IDBG-640204 and ENSBTAG00000034501 and 513197, complement factor I |
| Identity: |
5394 |
| Gene: |
CFI |
More about : CFI |
| Long gene name: |
complement factor I |
| Synonyms gene: |
IF |
| Synonyms gene name: |
I factor (complement) |
| Synonyms: |
FI C3b-INA KAF |
| Synonyms name: |
Konglutinogen-activating factor C3b-inactivator |
| Locus: |
4q25 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
J02770 |
| Entrez gene record: |
3426 |
| Pubmed identfication: |
2956252 |
| RefSeq identity: |
NM_000204 |
| Classification: |
Complement system |
| Havana BLAST/BLAT: |
OTTHUMG00000161109 |
| Locus Specific Databases: |
CFIbase: Mutation registry for Factor I deficiency (previously known as IFbase) LRG_48 |