| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CD58 / LFA3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (FFPE): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the CD58 antibody should be determined by the researcher |
| Intented use: |
This CD58 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P19256 |
| Purity: |
Antigen affinity |
| Description: |
It binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells, The LFA3 gene is mapped to chromosome 1p13, This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), or lymphocyte function-associated antigen 3 (LFA-3), particularly macrophages, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to, which is the same location as CD2, CD58 |
| Immunogen: |
Amino acids F29-R215 from the human protein were used as the immunogen for the CD58 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CD58 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
cell surface, Cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CD58 / LFA3 |
| Short name: |
CD58 Antibody / LFA3 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CD58 molecule (Antibody to) / LFA3 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD58 and IDBG-101394 and ENSG00000116815 and 965, CD58 and IDBG-634482 and ENSBTAG00000040131 and 782186, Cell surfaces, ag3 and LFA-3 and LFA3, protein binding, this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007596 and blood coagulation and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0031225 and anchored component of membrane and cellular component this GO :0034113 and heterotypic cell-cell adhesion and biological process this GO :0050900 and leukocyte migration and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071346 and cellular response to interferon-gamma and biological process this GO :0071356 and cellular response to tumor necrosis factor and biological process this GO :2000484 and positive regulation of interleukin-8 secretion and biological process, this GO :0005102 : receptor binding, this GO :0005102 : receptor binding and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, CD58 molecule |
| Identity: |
1688 |
| Gene: |
CD58 |
More about : CD58 |
| Long gene name: |
CD58 molecule |
| Synonyms gene: |
LFA3 |
| Synonyms gene name: |
(lymphocyte function-associated antigen 3) , CD58 antigen |
| Locus: |
1p13, 1 |
| Discovery year: |
1989-04-06 |
| GenBank acession: |
BC005930 |
| Entrez gene record: |
965 |
| Pubmed identfication: |
9510189 |
| RefSeq identity: |
NM_001779 |
| Classification: |
CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000022749 |