| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
c-Abl |
| Specificity: |
This antibody reacts specifically with c-Abl |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human c-Abl |
| Gene ID: |
25 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Activity of c-Abl protein is negatively regulated by its SH3 domain, The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, The t(9, [provided by RefSeq], and deletion of the SH3 domain turns ABL1 into an oncogene, and stress response, cell adhesion, cell division, suggesting a cell cycle function for ABL1, with alternatively spliced first exons spliced to the common exons 2-11, 22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia, The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
JTK7 c-ABL p150 |
| Also known as: |
c-Abl Polyclonal Antibody |
| Other name: |
Anti-c-Abl Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
c-Abl |
| Short name: |
Anti-c-Abl (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-c-Abl (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
76 |
| Gene: |
ABL1 |
More about : ABL1 |
| Long gene name: |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
| Synonyms gene: |
ABL |
| Synonyms gene name: |
non-receptor tyrosine kinase , receptor tyrosine kinase c-abl oncogene 1, v-abl Abelson murine leukemia viral oncogene homolog 1 c-abl oncogene 1 |
| Locus: |
9q34, 12 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M14752 |
| Entrez gene record: |
25 |
| Pubmed identfication: |
1857987 12626632 |
| RefSeq identity: |
NM_007313 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000020813 |
| Locus Specific Databases: |
LRG_769 |