| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
NLRC4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the NLRC4 antibody should be determined by the researcher |
| Intented use: |
This NLRC4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9NPP4 |
| Purity: |
Antigen affinity |
| Description: |
Alternative splicing results in multiple transcript variants, Family members play essential roles in innate immune response to a wide range of pathogenic organisms, It is mapped to 2p22, Mutations in this gene result in autoinflammation with infantile enterocolitis, This gene encodes a member of the caspase recruitment domain-containing NLR family, also known as CARD12, is a protein that in humans is encoded by the NLRC4 gene, tissue damage and other cellular stresses, 3, NLR family CARD domain-containing protein 4 |
| Immunogen: |
Amino acids KILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDR of human NLRC4/CARD12 were used as the immunogen for the NLRC4 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the NLRC4 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
NLRC4 |
| Short name: |
NLRC4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CARD domain containing 4 (Antibody to), NLR family |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CARD domain containing 4, Cytoplasm, NLRC4 and IDBG-43398 and ENSG00000091106 and 58484, NLRC4 and IDBG-631977 and ENSBTAG00000008223 and 512480, Nlrc4 and IDBG-197890 and ENSMUSG00000039193 and 268973, leucine rich repeat containing receptor signaling pathway and biological process this GO :0042742 and defense response to bacterium and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043281 and regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0050702 and interleukin-1 beta secretion and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051260 and protein homooli this GO merization and biological process this GO :0070269 and pyroptosis and biological process this GO :0072557 and IPAF inflammasome complex and cellular component, protein homodimerization activity, this GO :0000287 and magnesium ion binding and molecular function this GO :0002218 and activation of innate immune response and biological process this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005829 and cytosol and cellular component this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0016045 and detection of bacterium and biological process this GO :0035872 and nucleotide-binding domain, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, NLR family |
| Identity: |
16412 |
| Gene: |
NLRC4 |
More about : NLRC4 |
| Long gene name: |
NLR family CARD domain containing 4 |
| Synonyms gene: |
CARD12 |
| Synonyms gene name: |
caspase recruitment domain family, member 12 |
| Synonyms: |
CLAN1 ipaf CLANA CLANB CLANC CLAND CLR2, 1 CLAN |
| Synonyms name: |
leucine rich repeat and CARD domain containing 4 NOD-like receptor C4 , nucleotide-binding oligomerization domain |
| Locus: |
2p22, 3 |
| Discovery year: |
2002-09-19 |
| GenBank acession: |
AF376061 |
| Entrez gene record: |
58484 |
| Pubmed identfication: |
11374873 |
| RefSeq identity: |
NM_021209 |
| Classification: |
Caspase recruitment domain containing NLR family |
| Havana BLAST/BLAT: |
OTTHUMG00000152107 |