| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CDK5 |
| Specificity: |
Due to similar amino acid composition of this protein to CDK3 in human, based on an 83% sequence similarity, there is a chance that this antibody will react with CDK3 in human, CDK5, This antibody will detect both isoform variants of this protein |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CDK5 |
| Gene ID: |
1020 |
| Swiss Prot: |
Q00535 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Cdk5 activity is involved in terminal differentiation of neurons and muscle cells, Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, Instead, It is present in numerous mammalian tissues including kidney, Its activity is detected almost exclusively in brain extracts, MAP2 and NF-H and NF-M, Neuronal and muscle cells contain the highest amount of this protein, Similar to other Cdks, TAU, activates Cdk5, and ovary, but Cdk5 is not activated by cyclins, monomeric Cdk5 displays no enzymatic activity, phosphorylates synaptic protein Pctaire1, regulates acetylcholine receptor expression, testes, the p35 protein, which is expressed solely in the brain, CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases, CDK5 is serine/threonine kinase involved in synaptic regulation and neuronal development |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PSSALRE |
| Also known as: |
CDK5 Polyclonal Antibody |
| Other name: |
Anti-CDK5 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CDK5 |
| Short name: |
Anti-CDK5 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-cyclin-dependent kinase 5 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CDK5 and IDBG-48977 and ENSG00000164885 and 1020, CDK5 and IDBG-637527 and ENSBTAG00000007766 and 281066, Cdk5 and IDBG-141112 and ENSMUSG00000028969 and 12568, DNA-templated and biological process this GO :0045956 and positive regulation of calcium ion-dependent exocytosis and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046826 and negative regulation of protein export from nucleus and biological process this GO :0046875 and ephrin receptor binding and molecular function this GO :0048148 and behavioral response to cocaine and biological process this GO :0048167 and regulation of synaptic plasticity and biological process this GO :0048488 and synaptic vesicle endocytosis and biological process this GO :0048511 and rhythmic process and biological process this GO :0048675 and axon extension and biological process this GO :0048709 and oli this GO dendrocyte differentiation and biological process this GO :0048812 and neuron projection morphogenesis and biological process this GO :0048813 and dendrite morphogenesis and biological process this GO :0050321 and tau-protein kinase activity and molecular function this GO :0051301 and cell division and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0060078 and regulation of postsynaptic membrane potential and biological process this GO :0060079 and regulation of excitatory postsynaptic membrane potential and biological process this GO :0061001 and regulation of dendritic spine morphogenesis and biological process this GO :0070509 and calcium ion import and biological process this GO :0071156 and regulation of cell cycle arrest and biological process this GO :0090314 and positive regulation of protein targeting to membrane and biological process this GO :1901215 and negative regulation of neuron death and biological process this GO :2000251 and positive regulation of actin cytoskeleton reorganization and biological process this GO :2000273 and positive regulation of receptor activity and biological process, PSSALRE, dopaminergic and biological process this GO :0002039 and p53 binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004693 and cyclin-dependent protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005176 and ErbB-2 class receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006886 and intracellular protein transport and biological process this GO :0006887 and exocytosis and biological process this GO :0006913 and nucleocytoplasmic transport and biological process this GO :0006915 and apoptotic process and biological process this GO :0007049 and cell cycle and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007409 and axonogenesis and biological process this GO :0007411 and axon guidance and biological process this GO :0007416 and synapse assembly and biological process this GO :0007519 and skeletal muscle tissue development and biological process this GO :0007596 and blood coagulation and biological process this GO :0008045 and motor neuron axon guidance and biological process this GO :0008092 and cytoskeletal protein binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008306 and associative learning and biological process this GO :0008542 and visual learning and biological process this GO :0009611 and response to wounding and biological process this GO :0009790 and embryo development and biological process this GO :0014044 and Schwann cell development and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0016020 and membrane and cellular component this GO :0016079 and synaptic vesicle exocytosis and biological process this GO :0016301 and kinase activity and molecular function this GO :0016310 and phosphorylation and biological process this GO :0016477 and cell migration and biological process this GO :0016533 and cyclin-dependent protein kinase 5 holoenzyme complex and cellular component this GO :0016772 and transferase activity, glutamatergic and biological process this GO :0035418 and protein localization to synapse and biological process this GO :0042220 and response to cocaine and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0043113 and receptor clustering and biological process this GO :0043125 and ErbB-3 class receptor binding and molecular function this GO :0043204 and perikaryon and cellular component this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0045055 and regulated secretory pathway and biological process this GO :0045211 and postsynaptic membrane and cellular component this GO :0045786 and negative regulation of cell cycle and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0045861 and negative regulation of proteolysis and biological process this GO :0045892 and negative regulation of transcription, nuclei, this GO :0001764 and neuron migration and biological process this GO :0001963 and synaptic transmission, this GO :0002039 : p53 binding, this GO :0002039 : p53 binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004693 : cyclin-dependent protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005176 : ErbB-2 class receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008092 : cytoskeletal protein binding and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004693 : cyclin-dependent protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005176 : ErbB-2 class receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008092 : cytoskeletal protein binding, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0030549 : acetylcholine receptor activator activity, this GO :0043125 : ErbB-3 class receptor binding, this GO :0046875 : ephrin receptor binding, this GO :0050321 : tau-protein kinase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0030549 : acetylcholine receptor activator activity and also this GO :0043125 : ErbB-3 class receptor binding and also this GO :0046875 : ephrin receptor binding and also this GO :0050321 : tau-protein kinase activity, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0019233 and sensory perception of pain and biological process this GO :0021537 and telencephalon development and biological process this GO :0021549 and cerebellum development and biological process this GO :0021695 and cerebellar cortex development and biological process this GO :0021697 and cerebellar cortex formation and biological process this GO :0021766 and hippocampus development and biological process this GO :0021819 and layer formation in cerebral cortex and biological process this GO :0021954 and central nervous system neuron development and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0022038 and corpus callosum development and biological process this GO :0030027 and lamellipodium and cellular component this GO :0030054 and cell junction and cellular component this GO :0030175 and filopodium and cellular component this GO :0030182 and neuron differentiation and biological process this GO :0030334 and regulation of cell migration and biological process this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0030426 and growth cone and cellular component this GO :0030517 and negative regulation of axon extension and biological process this GO :0030549 and acetylcholine receptor activator activity and molecular function this GO :0030866 and cortical actin cytoskeleton organization and biological process this GO :0030900 and forebrain development and biological process this GO :0031175 and neuron projection development and biological process this GO :0031397 and negative regulation of protein ubiquitination and biological process this GO :0031594 and neuromuscular junction and cellular component this GO :0031914 and negative regulation of synaptic plasticity and biological process this GO :0032092 and positive regulation of protein binding and biological process this GO :0032801 and receptor catabolic process and biological process this GO :0033136 and serine phosphorylation of STAT3 protein and biological process this GO :0035249 and synaptic transmission, cyclin-dependent kinase 5 |
| Identity: |
1774 |
| Gene: |
CDK5 |
More about : CDK5 |
| Long gene name: |
cyclin dependent kinase 5 |
| Locus: |
7q36, 1 |
| Discovery year: |
1993-07-28 |
| GenBank acession: |
X66364 |
| Entrez gene record: |
1020 |
| Pubmed identfication: |
8275715 1639063 |
| Classification: |
Cyclin dependent kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000158414 |