| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
GCN5 / KAT2A |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the GCN5 antibody should be determined by the researcher |
| Intented use: |
This GCN5 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q92830 |
| Purity: |
Antigen affinity |
| Description: |
GCN4 and the HAP2-HAP3-HAP4 complex, GCN5 also functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT-independent manner, It is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator, The GCN4 protein activates transcription of a large number of amino acid biosynthetic genes under limiting amino acid conditions and the HAP2-HAP3-HAP4 complex is thought to mediate transcription of genes involved in respiratory functions, The GCN5 protein, a regulator of transcription activation in yeast, also called GCN5 and GCN5L2, is an enzyme that in humans is encoded by the KAT2A gene, promotes maximal levels of transcription by 2 transcriptional activators, Histone acetyltransferase KAT2A |
| Immunogen: |
Amino acids DPARPGLSQQQRASQRKAQVRGLPRAKKLEKL of human KAT2A/GCN5 were used as the immunogen for the GCN5 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the GCN5 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
GCN5 / KAT2A |
| Short name: |
GCN5 Antibody / KAT2A |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
GCN5 (Antibody to) / K(lysine) acetyltransferase 2A |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0007399 and nervous system development and biological process this GO :0008080 and N-acetyltransferase activity and molecular function this GO :0008152 and metabolic process and biological process this GO :0008283 and cell proliferation and biological process this GO :0010484 and H3 histone acetyltransferase activity and molecular function this GO :0016032 and viral process and biological process this GO :0016573 and histone acetylation and biological process this GO :0016578 and histone deubiquitination and biological process this GO :0021537 and telencephalon development and biological process this GO :0022037 and metencephalon development and biological process this GO :0030901 and midbrain development and biological process this GO :0030914 and STAGA complex and cellular component this GO :0031647 and regulation of protein stability and biological process this GO :0033276 and transcription factor TFTC complex and cellular component this GO :0035264 and multicellular organism growth and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0043966 and histone H3 acetylation and biological process this GO :0043983 and histone H4-K12 acetylation and biological process this GO :0043997 and histone acetyltransferase activity (H4-K12 specific) and molecular function this GO :0044154 and histone H3-K14 acetylation and biological process this GO :0045722 and positive regulation of gluconeogenesis and biological process this GO :0072686 and mitotic spindle and cellular component, GCN5 and GCN5L2 and hGCN5 and PCAF-b, KAT2A and IDBG-50287 and ENSG00000108773 and 2648, KAT2A and IDBG-640143 and ENSBTAG00000044019 and 514420, Kat2a and IDBG-211539 and ENSMUSG00000020918 and 14534, histone acetyltransferase activity (H4-K12 specific), nuclei, this GO :0000123 and histone acetyltransferase complex and cellular component this GO :0001701 and in utero embryonic development and biological process this GO :0001756 and somitogenesis and biological process this GO :0001843 and neural tube closure and biological process this GO :0003682 and chromatin binding and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0004402 and histone acetyltransferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005671 and Ada2/Gcn5/Ada3 transcription activator complex and cellular component this GO :0006325 and chromatin organization and biological process this GO :0006338 and chromatin remodeling and biological process this GO :0006355 and regulation of transcription, this GO :0003682 : chromatin binding, this GO :0003682 : chromatin binding and also this GO :0003713 : transcription coactivator activity and also this GO :0004402 : histone acetyltransferase activity and also this GO :0005515 : protein binding and also this GO :0008080 : N-acetyltransferase activity and also this GO :0010484 : H3 histone acetyltransferase activity and also this GO :0042826 : histone deacetylase binding and also this GO :0043997 : histone acetyltransferase activity (H4-K12 specific), this GO :0003713 : transcription coactivator activity, this GO :0004402 : histone acetyltransferase activity, this GO :0005515 : protein binding, this GO :0008080 : N-acetyltransferase activity, this GO :0010484 : H3 histone acetyltransferase activity, this GO :0042826 : histone deacetylase binding, this GO :0043997 : histone acetyltransferase activity (H4-K12 specific), K(lysine) acetyltransferase 2A |
| Identity: |
4201 |
| Gene: |
KAT2A |
More about : KAT2A |
| Long gene name: |
lysine acetyltransferase 2A |
| Synonyms gene: |
GCN5L2 |
| Synonyms gene name: |
GCN5 general control of amino-acid synthesis 5-like 2 (yeast) K(lysine) acetyltransferase 2A |
| Synonyms: |
GCN5 PCAF-b |
| Locus: |
17q21, 2 |
| Discovery year: |
1996-12-17 |
| GenBank acession: |
AF029777 |
| Entrez gene record: |
2648 |
| Pubmed identfication: |
8552087 |
| RefSeq identity: |
NM_021078 |
| Classification: |
Lysine acetyltransferases GCN5 related N-acetyltransferases ATAC complex SAGA complex |
| Havana BLAST/BLAT: |
OTTHUMG00000133504 |