| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ULK3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the ULK3 antibody should be determined by the researcher |
| Intented use: |
This ULK3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q6PHR2 |
| Purity: |
Antigen affinity |
| Description: |
Also, And ULK3 enhances endogenous and over-expressed GLI1 and GLI2 transcriptional activity in cultured cells, Besides that, In search of potential homologues to Drosophila and human Fu, It is demonstrated that ULK3 is widely expressed and its expression is higher in a number of tissues where Shh signaling is known to be active, It is showed that ULK3 is an autophosphorylated kinase and phosphorylates GLI proteins in vitro, The data suggest that serine/threonine kinase ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins, ULK3 alters subcellular localization of GLI1, ULK3 catalytical activity is crucial for its function in SHH pathway, as assessed by GLI-luciferase reporter assay, as assessed by immunofluorescent staining and immunoblotting assays, mediators of SHH signaling, people have cloned human serine/threonine kinase ULK3 and assessed its ability to regulate GLI transcription factors, Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy |
| Immunogen: |
Amino acids HTEVQNLMARAEYLKEQVKMRESRWEAD of human ULK3 were used as the immunogen for the ULK3 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ULK3 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
Cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ULK3 |
| Short name: |
ULK3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ULK3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
19703 |
| Gene: |
ULK3 |
More about : ULK3 |
| Long gene name: |
unc-51 like kinase 3 |
| Synonyms gene name: |
elegans) , unc-51-like kinase 3 (C |
| Synonyms: |
DKFZP434C131 FLJ90566 |
| Locus: |
15q24, 1 |
| Discovery year: |
2005-01-19 |
| GenBank acession: |
BC048289 |
| Entrez gene record: |
25989 |
| RefSeq identity: |
NM_015518 |
| Havana BLAST/BLAT: |
OTTHUMG00000173020 |