| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ACE |
| Specificity: |
This antibody reacts specifically with ACE |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from cat ACE1 |
| Gene ID: |
101094061 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ACE converts angiotensin I to angiotensin II by release of the terminal His-Leu, ACE exists in two forms, Also able to inactivate bradykinin, Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance, The germinal form is expressed by spermatozoa, The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), This enzyme plays a key role in the renin-angiotensin system, a 170KD somatic form and a 90KD germinal form, a potent vasodilatator, by some neuronal cells and variably by some macrophages and T lymphocytes, epithelial cells (especially in proximal renal tubules and small intestine), this results in an increase of the vasoconstrictor activity of angiotensin, Angiotensin Converting enzyme is involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ACE1 CD143 |
| Also known as: |
ACE Polyclonal Antibody |
| Other name: |
Anti-ACE Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ACE |
| Short name: |
Anti-ACE (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, Uncharacterized protein (polyclonal), antibody to-Angiotensin-converting enzyme |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ACE and IDBG-728302 and ENSG00000264813 and, Plasma membranes, Uncharacterized protein, peptidyl-dipeptidase activity, this GO :0006508 and proteolysis and biological process this GO :0008237 and metallopeptidase activity and molecular function this GO :0008241 and peptidyl-dipeptidase activity and molecular function this GO :0016020 and membrane and cellular component, this GO :0008237 : metallopeptidase activity, this GO :0008237 : metallopeptidase activity and also this GO :0008241 : peptidyl-dipeptidase activity, this GO :0008241 : peptidyl-dipeptidase activity, Angiotensin-converting enzyme |
| Identity: |
2707 |
| Gene: |
ACE |
More about : ACE |
| Long gene name: |
angiotensin I converting enzyme |
| Synonyms gene: |
DCP1 |
| Synonyms gene name: |
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 |
| Synonyms name: |
peptidyl-dipeptidase A |
| Locus: |
17q23, 3 |
| Discovery year: |
1989-06-06 |
| GenBank acession: |
J04144 |
| Entrez gene record: |
1636 |
| Pubmed identfication: |
2554286 10319862 |
| Classification: |
CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000154927 |