| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
STIM1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the STIM1 antibody should be determined by the researcher |
| Intented use: |
This STIM1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13586 |
| Purity: |
Antigen affinity |
| Description: |
Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Alternative splicing of this gene results in multiple transcript variants, It is one of several genes located in the imprinted gene domain of 11p15, Mutations in this gene are associated with fatal classic Kaposi sarcoma, STIM1 has a single transmembranedomain, This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs), This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), This gene may play a role in malignancies and disease that involve this region, Wilms tumor, adrenocrotical carcinoma, an important tumor-suppressor gene region, and breast cancer, and is localized to the endoplasmic reticulum, and lung, and to a lesser extent to the plasma membrane, as well as early hematopoiesis, by mediating attachment to stromal cells, ectodermal dysplasia and tubular aggregate myopathy, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ovarian, rhabdomyosarcoma, with the 3' end of this gene situated 1, 5, 6 kb from the 5' end of the RRM1 gene, Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene |
| Immunogen: |
Amino acids AAEFCRIDKPLCHSEDEKLSFEAVRNIHKL of human STIM1 were used as the immunogen for the STIM1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the STIM1 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
membrane, Cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
STIM1 |
| Short name: |
STIM1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
STIM1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11386 |
| Gene: |
STIM1 |
More about : STIM1 |
| Long gene name: |
stromal interaction molecule 1 |
| Synonyms: |
GOK D11S4896E |
| Locus: |
11p15, 4 |
| Discovery year: |
1997-02-05 |
| GenBank acession: |
BC021300 U52426 |
| Entrez gene record: |
6786 |
| Pubmed identfication: |
8921403 11463338 11983428 |
| RefSeq identity: |
NM_003156 |
| Classification: |
Sterile alpha motif domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000133360 |
| Locus Specific Databases: |
LRG_164 |