| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
XRCC4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the XRCC4 antibody should be determined by the researcher |
| Intented use: |
This XRCC4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13426 |
| Purity: |
Antigen affinity |
| Description: |
Furthermore, In addition to humans, Since XRCC4 is the key protein that enables interaction of LigIV to damaged DNA and therefore ligation of the ends, The X-ray repair cross-complementing protein 4 is one of several coreproteins involved in the non-homologous end joining (NHEJ) pathway to repair DNA double strand breaks (DSBs), certain mutations in the XRCC4 gene are associated with an increased risk of cancer, fungi and in plants, mutations in the XRCC4 gene were found to cause embryonic lethality in mice and developmental inhibition and immunodeficiency in humans, the XRCC4 protein is also expressed in many other metazoans, X-ray repair cross-complementing protein 4 is a protein that in humans is encoded by the XRCC4 gene |
| Immunogen: |
Amino acids ESEISQEADDMAMEKGKYVGELRKALL of human XRCC4 were used as the immunogen for the XRCC4 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the XRCC4 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
Nuclear |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
XRCC4 |
| Short name: |
XRCC4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
X-ray repair complementing defective repair in Chinese hamster cells 4 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
XRCC4 and IDBG-32219 and ENSG00000152422 and 7518, XRCC4 and IDBG-646520 and ENSBTAG00000024275 and 613590, Xrcc4 and IDBG-171005 and ENSMUSG00000021615 and 108138, nuclei, protein C-terminus binding, this GO :0001701 and in utero embryonic development and biological process this GO :0002328 and pro-B cell differentiation and biological process this GO :0003677 and DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005813 and centrosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0005958 and DNA-dependent protein kinase-DNA ligase 4 complex and cellular component this GO :0006266 and DNA ligation and biological process this GO :0006281 and DNA repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0006303 and double-strand break repair via nonhomolo this GO us end joining and biological process this GO :0006310 and DNA recombination and biological process this GO :0007417 and central nervous system development and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0010165 and response to X-ray and biological process this GO :0010212 and response to ionizing radiation and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0016032 and viral process and biological process this GO :0030054 and cell junction and cellular component this GO :0032807 and DNA ligase IV complex and cellular component this GO :0033077 and T cell differentiation in thymus and biological process this GO :0033151 and V(D)J recombination and biological process this GO :0033152 and immunoglobulin V(D)J recombination and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045190 and isotype switching and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0050769 and positive regulation of neurogenesis and biological process this GO :0051103 and DNA ligation involved in DNA repair and biological process this GO :0051351 and positive regulation of ligase activity and biological process this GO :0070419 and nonhomolo this GO us end joining complex and cellular component this GO :0071285 and cellular response to lithium ion and biological process this GO :0075713 and establishment of integrated proviral latency and biological process, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0005515 : protein binding and also this GO :0008022 : protein C-terminus binding, this GO :0005515 : protein binding, this GO :0008022 : protein C-terminus binding, X-ray repair complementing defective repair in Chinese hamster cells 4 |
| Identity: |
12831 |
| Gene: |
XRCC4 |
More about : XRCC4 |
| Long gene name: |
X-ray repair cross complementing 4 |
| Synonyms gene name: |
X-ray repair complementing defective repair in Chinese hamster cells 4 |
| Synonyms name: |
X-ray repair, complementing defective, repair in Chinese hamster DNA repair protein XRCC4 |
| Locus: |
5q14, 2 |
| Discovery year: |
1990-10-16 |
| GenBank acession: |
AB017445 |
| Entrez gene record: |
7518 |
| Pubmed identfication: |
1697445 7665175 |
| RefSeq identity: |
NM_022550 |
| Havana BLAST/BLAT: |
OTTHUMG00000131319 |