| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CTBP1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the CTBP1 antibody should be determined by the researcher |
| Intented use: |
This CTBP1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13363 |
| Purity: |
Antigen affinity |
| Description: |
Alternative splicing of transcripts from this gene results in multiple transcript variants, Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development, C-terminal-binding protein 1, CTBP2, CtBP complexes with CtIP, CtBP1 and CtBP2 associate with the PLDLSL domain of ?EF1, CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif, CtBP1 is expressed from embryo to adult, CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity, During skeletal and T cell development, In addition, PLDLS, The CtBP1 protein binds to the C-terminus of adenovirus E1A proteins, This gene is mapped to 4p16, This protein and the product of a second closely related gene, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP, a cellular zinc finger-homeodomain protein, and thereby enhances ?EF1-induced transcriptional silencing, but CtBP2 is mainly expressed during embryogenesis, can dimerize, is a protein that in humans is encoded by the CTBP1 gene, to repress E1A induced oncogenesis and cellular transformation, CTBP1, This phosphoprotein is a transcriptional repressor (corepressor) and may play a role during cellular proliferation |
| Immunogen: |
Amino acids HGLPPVAHPPHAPSPGQTVKPEADRDHASDQL of human CTBP1 were used as the immunogen for the CTBP1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CTBP1 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CTBP1 |
| Short name: |
CTBP1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
C-terminal binding protein 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BARS, CTBP1 and IDBG-643874 and ENSBTAG00000008480 and 513131, CTBP1 and IDBG-6522 and ENSG00000159692 and 1487, Ctbp1 and IDBG-152845 and ENSMUSG00000037373 and 13016, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007030 and this GO lgi organization and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008134 and transcription factor binding and molecular function this GO :0008152 and metabolic process and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0016616 and oxidoreductase activity, DNA-templated and biological process this GO :0050872 and white fat cell differentiation and biological process this GO :0051287 and NAD binding and molecular function this GO :0051726 and regulation of cell cycle and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0090241 and negative regulation of histone H4 acetylation and biological process, NAD or NADP as acceptor, NAD or NADP as acceptor and also this GO :0019904 : protein domain specific binding and also this GO :0042803 : protein homodimerization activity and also this GO :0051287 : NAD binding and also this GO :0070491 : repressing transcription factor binding, NAD or NADP as acceptor and molecular function this GO :0017053 and transcriptional repressor complex and cellular component this GO :0019079 and viral genome replication and biological process this GO :0019904 and protein domain specific binding and molecular function this GO :0031065 and positive regulation of histone deacetylation and biological process this GO :0034401 and regulation of transcription by chromatin organization and biological process this GO :0035067 and negative regulation of histone acetylation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0045892 and negative regulation of transcription, acting on the CH-OH group of donors, acting on the CH-OH group of donors, acting on the CH-OH group of donors, nuclei, oxidoreductase activity, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001106 and RNA polymerase II transcription corepressor activity and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0004616 and phosphogluconate dehydrogenase (decarboxylating) activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005829 and cytosol and cellular component this GO :0006098 and pentose-phosphate shunt and biological process this GO :0006351 and transcription, this GO :0001106 : RNA polymerase II transcription corepressor activity, this GO :0001106 : RNA polymerase II transcription corepressor activity and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0004616 : phosphogluconate dehydrogenase (decarboxylating) activity and also this GO :0005515 : protein binding and also this GO :0008022 : protein C-terminus binding and also this GO :0008134 : transcription factor binding and also this GO :0016616 : oxidoreductase activity, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0004616 : phosphogluconate dehydrogenase (decarboxylating) activity, this GO :0005515 : protein binding, this GO :0008022 : protein C-terminus binding, this GO :0008134 : transcription factor binding, this GO :0016616 : oxidoreductase activity, this GO :0019904 : protein domain specific binding, this GO :0042803 : protein homodimerization activity, this GO :0051287 : NAD binding, this GO :0070491 : repressing transcription factor binding, C-terminal binding protein 1 |
| Identity: |
2494 |
| Gene: |
CTBP1 |
More about : CTBP1 |
| Long gene name: |
C-terminal binding protein 1 |
| Synonyms: |
BARS |
| Synonyms name: |
brefeldin A-ribosylated substrate |
| Locus: |
4p16, 3 |
| Discovery year: |
1997-08-22 |
| GenBank acession: |
U37408 |
| Entrez gene record: |
1487 |
| Pubmed identfication: |
9479502 |
| RefSeq identity: |
NM_001328 |
| Havana BLAST/BLAT: |
OTTHUMG00000089259 |