| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CtBP1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the CtBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CtBP1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13363 |
| Purity: |
Antigen affinity |
| Description: |
Alternative splicing of transcripts from this gene results in multiple transcript variants, Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development, CTBP2, CtBP complexes with CtIP, CtBP1 and -2 associate with the PLDLSL domain of delta EF1, CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif, CtBP1 is expressed from embryo to adult, CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity, During skeletal and T cell development, In addition, It binds to the C-terminus of adenovirus E1A proteins, It is a transcriptional repressor(corepressor) and may play a role during cellular proliferation, PLDLS, This protein and the product of a second closely related gene, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP, a cellular zinc finger-homeodomain protein, and thereby enhances delta EF1-induced transcriptional silencing, but CtBP2 is mainly expressed during embryogenesis, can dimerize, to repress E1A induced oncogenesis and cellular transformation, C-terminal-binding protein 1 is encoded by the CTBP1 gene |
| Immunogen: |
Amino acids 425-440 (QTVKPEADRDHASDQL-human) were used as the immunogen for this CtBP1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CtBP1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CtBP1 |
| Short name: |
CtBP1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
C-terminal binding protein 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2494 |
| Gene: |
CTBP1 |
More about : CTBP1 |
| Long gene name: |
C-terminal binding protein 1 |
| Synonyms: |
BARS |
| Synonyms name: |
brefeldin A-ribosylated substrate |
| Locus: |
4p16, 3 |
| Discovery year: |
1997-08-22 |
| GenBank acession: |
U37408 |
| Entrez gene record: |
1487 |
| Pubmed identfication: |
9479502 |
| RefSeq identity: |
NM_001328 |
| Havana BLAST/BLAT: |
OTTHUMG00000089259 |