| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Calcineurin / PPP3CA |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the Calcineurin A antibody should be determined by the researcher |
| Intented use: |
This Calcineurin A antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q08209 |
| Purity: |
Antigen affinity |
| Description: |
(1999) and Musaro et al, (1999) demonstrated that either IGF1 or activated calcineurin induces expression of transcription factor GATA2, (1999) found that hypertrophy was suppressed by the calcineurin inhibitors cyclosporin A or FK506, (1999) independently showed that IGF1stimulates skeletal muscle hypertrophy and a switch to glycolytic metabolism by activating calcineurin A and inducing the nuclear translocation of transcription factor NFATC1, (1999) showed that expression of a dominant-negative calcineurin mutant also repressed myocyte differentiation and hypertrophy, It is mapped to 4q24, Musaro et al, Musaro et al, Semsarian et al, Semsarian et al, but not by inhibitors of the MAP kinase or phosphatidylinositol-3-OH kinase pathways, where it associates with calcineurin and a specific dephosphorylated isoform of NFATC1, which accumulates in a subset of myocyte nuclei, Calcineurin A is also known as PPP3CA |
| Immunogen: |
Amino acids DAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ of human Calcineurin A were used as the immunogen for the Calcineurin A antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Calcineurin A antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Calcineurin / PPP3CA |
| Short name: |
Calcineurin Antibody / PPP3CA |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Calcineurin (Antibody to) / PPP3CA |
| Alternative technique: |
antibodies |
| Identity: |
9314 |
| Gene: |
PPP3CA |
More about : PPP3CA |
| Long gene name: |
protein phosphatase 3 catalytic subunit alpha |
| Synonyms gene: |
CALN CALNA |
| Synonyms gene name: |
alpha isoform (calcineurin A alpha) protein phosphatase 3 (formerly 2B), alpha isoform protein phosphatase 3, alpha isozyme , catalytic subunit, catalytic subunit, catalytic subunit, protein phosphatase 3 (formerly 2B) |
| Synonyms: |
CNA1 PPP2B |
| Synonyms name: |
alpha isoform , calcineurin A alpha protein phosphatase 2B, catalytic subunit |
| Locus: |
4q24 |
| Discovery year: |
1990-06-26 |
| Entrez gene record: |
5530 |
| Pubmed identfication: |
2848250 1659808 |
| RefSeq identity: |
NM_000944 |
| Classification: |
Protein phosphatase catalytic subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000133839 |