| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PMP22 |
| Specificity: |
This antibody reacts specifically with PMP22 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PMP-22 |
| Gene ID: |
5376 |
| Swiss Prot: |
Q01453 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Alterations in the level of this protein cause several genetic human diseases, If one copy of the gene is deleted, If the protein is duplicated, In the peripheral nervous system, PMP 22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) during nerve development and regeneration, patients develop Charcot Marie Tooth disease, they suffer from the inherited tendency to pressure palsies, PMP22 is a 22 kDa glycoprotein expressed in the compact myelin of the peripheral nervous system |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PMP22 |
| Also known as: |
PMP22 Polyclonal Antibody |
| Other name: |
Anti-PMP22 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PMP22 |
| Short name: |
Anti-PMP22 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PMP22 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
9716 |
| Gene: |
PXMP2 |
More about : PXMP2 |
| Long gene name: |
peroxisomal membrane protein 2 |
| Synonyms gene name: |
22kDa , peroxisomal membrane protein 2 (22kD) peroxisomal membrane protein 2 |
| Locus: |
12q24, 33 |
| Discovery year: |
1992-03-03 |
| Entrez gene record: |
5827 |
| Pubmed identfication: |
11590176 |
| RefSeq identity: |
NM_018663 |
| Havana BLAST/BLAT: |
OTTHUMG00000168019 |