| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Ataxin 3 / ATXN3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the ATXN3 antibody should be determined by the researcher |
| Intented use: |
This ATXN3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P54252 |
| Purity: |
Antigen affinity |
| Description: |
1, 4, ATX3, ATXN3 ranges in size from 360 to 374 amino acids, Alternatively spliced transcript variants encoding different isoforms have been described for this gene, Ataxin-3 interacted with 2 human homologs of the yeast DNA repair protein RAD23, Both normal and mutant ataxin-3 proteins interacted with the ubiquitin-like domain at the N terminus of the HHR23 proteins, HHR23A (RAD23A) and HHR23B (RAD23B), HHR23A was recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3, However, JOS, MJD GENE, MJD1, Machado-Joseph disease, Machado-Joseph disease protein 1, SCA3 GENE, Spinocerebellar ataxia-3, The protein encoded by the ATXN3 gene contains (CAG)n repeats in the coding region, There is an inverse correlation between the age of onset and CAG repeat numbers, They detected at least 4 ATXN3 transcripts of 1, Using Northern blot analysis showed that ATXN3 mRNA was ubiquitously expressed in human tissues, also known as AT3, also known as spinocerebellar ataxia-3, and 7, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease, in HEK 293 cells, is a protein that in humans is encoded by the ATXN3 gene, is an autosomal dominant neurologic disorder, which is a motif important for nucleotide excision repair, 4, 5, 5 kb and suggested that the different mRNA species probably result from differential splicing and polyadenylation, 8, ATXN3 (Ataxin 3) |
| Immunogen: |
Amino acids EEDLQRALALSRQEIDMEDEEADLRRAIQ of human Ataxin 3 were used as the immunogen for the ATXN3 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ATXN3 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
Nuclear and cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Ataxin 3 / ATXN3 |
| Short name: |
Ataxin 3 Antibody / ATXN3 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Ataxin 3 (Antibody to) / ATXN3 |
| Alternative technique: |
antibodies |
| Identity: |
7106 |
| Gene: |
ATXN3 |
More about : ATXN3 |
| Long gene name: |
ataxin 3 |
| Synonyms gene: |
SCA3 MJD |
| Synonyms gene name: |
Machado-Joseph disease (spinocerebellar ataxia 3, ataxin 3) , autosomal dominant, olivopontocerebellar ataxia 3 |
| Synonyms: |
ATX3 JOS |
| Locus: |
14q32, 12 |
| Discovery year: |
1987-09-11 |
| GenBank acession: |
U64820 |
| Entrez gene record: |
4287 |
| Pubmed identfication: |
8358439 |
| RefSeq identity: |
NM_004993 |
| Classification: |
Ataxins MJD deubiquinating enzymes |
| Havana BLAST/BLAT: |
OTTHUMG00000162212 |
| Locus Specific Databases: |
LRG_865 |