| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
AT1R), Angiotensin II Type 1 Receptor (AGTR1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the AT1R antibody should be determined by the researcher |
| Intented use: |
This AT1R antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P30556 |
| Purity: |
Antigen affinity |
| Description: |
And it acts through at least two types of receptors, Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion, It is an important effector controlling blood pressure and volume in the cardiovascular system, It was previously thought that a related gene, Moreover, Multiple alternatively spliced transcript variants have been reported for this gene, This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II, denoted as AGTR1B, existed, however, is known as Angiotensin II Type 1 Receptor, it is now believed that there is only one type 1 receptor gene in humans, or AT1R, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium, AGTR1 |
| Immunogen: |
Amino acids MILNSSTEDGIKRIQDDCPKAGRHNYIF of human AGTR1 were used as the immunogen for the AT1R antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the AT1R antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
AT1R), Angiotensin II 1 Receptor (AGTR1 |
| Short name: |
AT1R), Angiotensin II 1 Receptor Antibody (AGTR1 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
AT1R), classification 1, Angiotensin II classification 1 Receptor (Antibody to) (angiotensin II receptor |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AG2S and AGTR1B and AT1 and AT1AR and AT1B and AT1BR and AT1R and AT2R1 and HAT1R, AGTR1 and IDBG-60289 and ENSG00000144891 and 185, AGTR1 and IDBG-647315 and ENSBTAG00000045633 and 281607, Plasma membranes, protein heterodimerization activity, this GO :0001558 and regulation of cell growth and biological process this GO :0001596 and angiotensin type I receptor activity and molecular function this GO :0001822 and kidney development and biological process this GO :0002018 and renin-angiotensin regulation of aldosterone production and biological process this GO :0002034 and regulation of blood vessel size by renin-angiotensin and biological process this GO :0003081 and regulation of systemic arterial blood pressure by renin-angiotensin and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004945 and angiotensin type II receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007200 and phospholipase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007266 and Rho protein signal transduction and biological process this GO :0010744 and positive regulation of macrophage derived foam cell differentiation and biological process this GO :0010873 and positive regulation of cholesterol esterification and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0019229 and regulation of vasoconstriction and biological process this GO :0019722 and calcium-mediated signaling and biological process this GO :0031711 and bradykinin receptor binding and molecular function this GO :0032270 and positive regulation of cellular protein metabolic process and biological process this GO :0032430 and positive regulation of phospholipase A2 activity and biological process this GO :0033864 and positive regulation of NAD(P)H oxidase activity and biological process this GO :0034374 and low-density lipoprotein particle remodeling and biological process this GO :0035813 and regulation of renal sodium excretion and biological process this GO :0038166 and angiotensin-activated signaling pathway and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042312 and regulation of vasodilation and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0050727 and regulation of inflammatory response and biological process this GO :0050729 and positive regulation of inflammatory response and biological process this GO :0051482 and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway and biological process this GO :0060326 and cell chemotaxis and biological process this GO :0086097 and phospholipase C-activating angiotensin-activated signaling pathway and biological process this GO :2000379 and positive regulation of reactive oxygen species metabolic process and biological process, this GO :0001596 : angiotensin type I receptor activity, this GO :0001596 : angiotensin type I receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004945 : angiotensin type II receptor activity and also this GO :0005515 : protein binding and also this GO :0031711 : bradykinin receptor binding and also this GO :0046982 : protein heterodimerization activity, this GO :0004930 : G-protein coupled receptor activity, this GO :0004945 : angiotensin type II receptor activity, this GO :0005515 : protein binding, this GO :0031711 : bradykinin receptor binding, this GO :0046982 : protein heterodimerization activity, type 1, angiotensin II receptor |
| Identity: |
336 |
| Gene: |
AGTR1 |
More about : AGTR1 |
| Long gene name: |
angiotensin II receptor type 1 |
| Synonyms gene: |
AGTR1B |
| Synonyms gene name: |
angiotensin receptor 1B |
| Synonyms: |
AT1 AT2R1 AGTR1A AT2R1A HAT1R AG2S AT2R1B AT1B |
| Locus: |
3q24 |
| Discovery year: |
1992-08-25 |
| GenBank acession: |
M87290 |
| Entrez gene record: |
185 |
| Pubmed identfication: |
1550596 |
| Classification: |
Angiotensin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000159503 |