| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GLP-1 |
| Specificity: |
This antibody reacts specifically with GLP-1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GLP-1 |
| Gene ID: |
2641 |
| Swiss Prot: |
P01275 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A counterregulatory hormone of insulin, CRH, GLP-1 is a potent stimulator of glucose-dependent insulin release, GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity, Have growth-promoting activities on intestinal epithelium, Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation, Inhibits beta cell apoptosis, Inhibits gastric emptying in humans, May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, May play an important role in intestinal mucosal growth in the early period of life, Oxyntomodulin significantly reduces food intake, Play important roles on gastric motility and the suppression of plasma glucagon levels, Plays a key role in nutrient homeostasis, Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes, Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis, Stimulates intestinal glucose transport and decreases mucosal permeability, Suppression of gastric emptying may lead to increased gastric distension, TSH, The gastrointestinal tract, and vasopressin secretion, as well as increasing nutrient disposal, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis, enhancing nutrient assimilation through enhanced gastrointestinal function, from the stomach to the colon is the principal target for GLP-2 action, independent of the actions of insulin, oxytocin, raises plasma glucose levels in response to insulin-induced hypoglycemia, which may contribute to satiety by causing a sensation of fullness, Glucagon plays a key role in glucose metabolism and homeostasis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
GLP1 GLP-1 GATAD3 |
| Also known as: |
GLP-1 Polyclonal Antibody |
| Other name: |
Anti-GLP-1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GLP-1 |
| Short name: |
Anti-GLP-1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-GLP-1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
37245 |
| Gene: |
ZGLP1 |
More about : ZGLP1 |
| Long gene name: |
GATA-like protein 1 , zinc finger |
| Synonyms name: |
GATA like protein 1 GATA zinc finger domain containing 3 |
| Locus: |
19p13, 2 |
| Discovery year: |
2009-10-02 |
| GenBank acession: |
AK096830 |
| Entrez gene record: |
100125288 |
| Pubmed identfication: |
16982049 |
| RefSeq identity: |
NM_001103167 |
| Classification: |
GATA zinc finger domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000152114 |