| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
IDE |
| Specificity: |
This antibody reacts specifically with IDE |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cell membrane, Secreted, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human IDE |
| Gene ID: |
3416 |
| Swiss Prot: |
P14735 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Degrades amyloid formed by APP and IAPP, IAPP, May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia, and thereby plays a role in intercellular peptide signaling, bradykinin, glucagon, kallidin and other peptides, Plays a role in the cellular breakdown of insulin |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
IDE Polyclonal Antibody |
| Other name: |
Anti-IDE Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
IDE |
| Short name: |
Anti-IDE (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-insulin-degrading enzyme (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
IDE and IDBG-637578 and ENSBTAG00000019759 and 523752, IDE and IDBG-82456 and ENSG00000119912 and 3416, INSULYSIN, Ide and IDBG-161417 and ENSMUSG00000056999 and 15925, metal ion binding, nuclei, this GO :0001540 and beta-amyloid binding and molecular function this GO :0001948 and glycoprotein binding and molecular function this GO :0003824 and catalytic activity and molecular function this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005777 and peroxisome and cellular component this GO :0005782 and peroxisomal matrix and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006508 and proteolysis and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008340 and determination of adult lifespan and biological process this GO :0009986 and cell surface and cellular component this GO :0010815 and bradykinin catabolic process and biological process this GO :0010992 and ubiquitin homeostasis and biological process this GO :0016032 and viral process and biological process this GO :0016887 and ATPase activity and molecular function this GO :0017046 and peptide hormone binding and molecular function this GO :0031597 and cytosolic proteasome complex and cellular component this GO :0031626 and beta-endorphin binding and molecular function this GO :0032461 and positive regulation of protein oli this GO merization and biological process this GO :0042277 and peptide binding and molecular function this GO :0042447 and hormone catabolic process and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043130 and ubiquitin binding and molecular function this GO :0043559 and insulin binding and molecular function this GO :0044257 and cellular protein catabolic process and biological process this GO :0045861 and negative regulation of proteolysis and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050435 and beta-amyloid metabolic process and biological process this GO :0051260 and protein homooli this GO merization and biological process this GO :0051289 and protein homotetramerization and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051603 and proteolysis involved in cellular protein catabolic process and biological process this GO :1901142 and insulin metabolic process and biological process this GO :1901143 and insulin catabolic process and biological process, this GO :0001540 : beta-amyloid binding, this GO :0001540 : beta-amyloid binding and also this GO :0001948 : glycoprotein binding and also this GO :0003824 : catalytic activity and also this GO :0004222 : metalloendopeptidase activity and also this GO :0005102 : receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008270 : zinc ion binding and also this GO :0016887 : ATPase activity and also this GO :0017046 : peptide hormone binding and also this GO :0031626 : beta-endorphin binding and also this GO :0042277 : peptide binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043130 : ubiquitin binding and also this GO :0043559 : insulin binding and also this GO :0046872 : metal ion binding, this GO :0001948 : glycoprotein binding, this GO :0003824 : catalytic activity, this GO :0004222 : metalloendopeptidase activity, this GO :0005102 : receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008270 : zinc ion binding, this GO :0016887 : ATPase activity, this GO :0017046 : peptide hormone binding, this GO :0031626 : beta-endorphin binding, this GO :0042277 : peptide binding, this GO :0042803 : protein homodimerization activity, this GO :0043130 : ubiquitin binding, this GO :0043559 : insulin binding, this GO :0046872 : metal ion binding, insulin-degrading enzyme |
| Identity: |
5381 |
| Gene: |
IDE |
More about : IDE |
| Long gene name: |
insulin degrading enzyme |
| Synonyms gene name: |
insulin-degrading enzyme |
| Synonyms name: |
insulysin |
| Locus: |
10q23, 33 |
| Discovery year: |
1990-07-03 |
| GenBank acession: |
M21188 |
| Entrez gene record: |
3416 |
| Pubmed identfication: |
2293021 |
| RefSeq identity: |
NM_004969 |
| Havana BLAST/BLAT: |
OTTHUMG00000018759 |