| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Oncostatin M / OSM |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the OSM antibody should be determined by the researcher |
| Intented use: |
This OSM antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P13725 |
| Purity: |
Antigen affinity |
| Description: |
CSF3, G-CSF and GM-CSF from endothelial cells, It has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts, It regulates cytokine production, Oncostatin M also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, The OSM gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines, The direction of gene transcription was telomeric to centromeric, Treatment with recombinant Oncostatin M leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types, a function shared by LIF, and IL6, and interleukin 6, granulocyte colony-stimulating factor, including IL-6, with the OSM gene located upstream of the LIF gene, Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor |
| Immunogen: |
Amino acids 26-220 of human Oncostatin M were used as the immunogen for the OSM antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the OSM antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
cytoplasmic, Nuclear |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Oncostatin M / OSM |
| Short name: |
Oncostatin M Antibody / OSM |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Oncostatin M (Antibody to) / oncostatin M |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, Extracellular, OSM and IDBG-4002 and ENSG00000099985 and 5008, Osm and IDBG-142284 and ENSMUSG00000058755 and 18413, growth factor activity, this GO :0002675 and positive regulation of acute inflammatory response and biological process this GO :0005125 and cytokine activity and molecular function this GO :0005147 and oncostatin-M receptor binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005900 and oncostatin-M receptor complex and cellular component this GO :0006955 and immune response and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007422 and peripheral nervous system development and biological process this GO :0008083 and growth factor activity and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009408 and response to heat and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0040008 and regulation of growth and biological process this GO :0042503 and tyrosine phosphorylation of Stat3 protein and biological process this GO :0042506 and tyrosine phosphorylation of Stat5 protein and biological process this GO :0042508 and tyrosine phosphorylation of Stat1 protein and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0045835 and negative regulation of meiosis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046888 and negative regulation of hormone secretion and biological process this GO :0048266 and behavioral response to pain and biological process this GO :0050731 and positive regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0051781 and positive regulation of cell division and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, this GO :0005125 : cytokine activity, this GO :0005125 : cytokine activity and also this GO :0005147 : oncostatin-M receptor binding and also this GO :0008083 : growth factor activity, this GO :0005147 : oncostatin-M receptor binding, this GO :0008083 : growth factor activity, 45038 and IDBG-636338 and ENSBTAG00000016163 and 319086, oncostatin M |
| Identity: |
8506 |
| Gene: |
OSM |
More about : OSM |
| Long gene name: |
oncostatin M |
| Synonyms: |
MGC20461 |
| Locus: |
22q12, 2 |
| Discovery year: |
1992-07-09 |
| GenBank acession: |
AF129855 |
| Entrez gene record: |
5008 |
| Pubmed identfication: |
1717982 |
| RefSeq identity: |
NM_020530 |
| Classification: |
Interleukin 6 cytokine family |
| Havana BLAST/BLAT: |
OTTHUMG00000150913 |