| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Pokemon / ZBTB7A |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the Pokemon antibody should be determined by the researcher |
| Intented use: |
This Pokemon antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O95365 |
| Purity: |
Antigen affinity |
| Description: |
Inactivation of ZBTB7A in vivo leads to RB downregulation, It has a critical oncosuppressive role in the prostate, It has been showed that ZBTB7A physically interacts with SOX9 and functionally antagonizes its transcriptional activity on key target genes such as MIA, Notably, Prostate-specific inactivation of ZBTB7A leads to a marked acceleration of PTEN loss-driven prostate tumorigenesis through bypass of PTEN loss-induced cellular senescence, Therefore, ZBTB7A is identified as a context-dependent cancer gene that can act as an oncogene in some contexts but that also has oncosuppressive-like activity in PTEN-null tumors, a long noncoding RNA precursor for an RB-targeting microRNA, also called Pokemon and FBI-1, and H19, and invasive prostate cancer, as well as downregulated at both the mRNA and protein levels, bypass of PTEN loss-induced cellular senescence, in a subset of human advanced prostate cancers, is a protein that in humans is encoded by the ZBTB7A gene, it has been also found that ZBTB7A is genetically lost, which is involved in tumor cell invasion, Zinc finger and BTB domain-containing protein 7A |
| Immunogen: |
Amino acids DLLDRQILAADAGADAGQLDLVDQIDQRNLLRAKEYLEF of human ZBTB7A were used as the immunogen for the Pokemon antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Pokemonantibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
Nuclear |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Pokemon / ZBTB7A |
| Short name: |
Pokemon Antibody / ZBTB7A |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Pokemon (Antibody to) / ZBTB7A |
| Alternative technique: |
antibodies |
| Identity: |
18078 |
| Gene: |
ZBTB7A |
More about : ZBTB7A |
| Long gene name: |
zinc finger and BTB domain containing 7A |
| Synonyms gene: |
ZBTB7 |
| Synonyms gene name: |
zinc finger and BTB domain containing 7 |
| Synonyms: |
FBI-1 LRF DKFZp547O146 pokemon ZNF857A |
| Synonyms name: |
HIV-1 inducer of short transcripts binding protein lymphoma related factor , zinc finger and BTB domain containing 7A |
| Locus: |
19p13, 3 |
| Discovery year: |
2004-01-16 |
| GenBank acession: |
AF000561 |
| Entrez gene record: |
51341 |
| Pubmed identfication: |
9973611 9927193 |
| RefSeq identity: |
NM_015898 |
| Classification: |
BTB domain containing Zinc fingers C2H2-type |
| Havana BLAST/BLAT: |
OTTHUMG00000181792 |