| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PKC iota |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the PKC iota antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This PKC iota antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
5584 |
| Purity: |
Antigen affinity |
| Description: |
It is also a hedgehog target gene that forms a positive feedback loop with GLI and exists at increased levels in basal cell carcinomas, It is not activated by phorbolesters or diacylglycerol, PRKCI is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis, This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases, This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, This protein kinase is calcium-independent and phospholipid-dependent, also called PKCI, is an enzyme that in humans is encoded by the PRKCI gene, where it phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway, Protein kinase C iota |
| Immunogen: |
Human partial recombinant protein (AA 21-214) was used as the immunogen for this PKC iota antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PKC iota antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PKC iota |
| Short name: |
PKC iota Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PKC iota (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
30500 |
| Gene: |
PRRT2 |
More about : PRRT2 |
| Long gene name: |
proline rich transmembrane protein 2 |
| Synonyms gene: |
ICCA DYT10 |
| Synonyms gene name: |
infantile convulsions and paroxysmal choreoathetosis dystonia 10 proline-rich transmembrane protein 2 |
| Synonyms: |
FLJ25513 DKFZp547J199 IFITMD1 FICCA DSPB3 PKC EKD1 |
| Synonyms name: |
interferon induced transmembrane protein domain containing 1 |
| Locus: |
16p11, 2 |
| Discovery year: |
2005-11-25 |
| GenBank acession: |
BC011405 |
| Entrez gene record: |
112476 |
| Pubmed identfication: |
22101681 22243967 |
| RefSeq identity: |
NM_145239 |
| Classification: |
Proline rich transmembrane proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000177142 |