| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
GPX1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the GPX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This GPX1 antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
2876 |
| Purity: |
Antigen affinity |
| Description: |
GPX-1 is an enzyme that in humans is encoded by the GPX1 gene, GPX1 is one of only a few proteins known in higher vertebrates to contain selenocysteine, Glutathione peroxidase functions in the detoxification of hydrogen peroxide, It has been reported that the protein encoded by this gene protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, It is mapped to 3p21, This gene encodes a member of the glutathione peroxidase family consisting of eight known glutathione peroxidases (Gpx1-8) in humans, also known as, and is one of the most important antioxidant enzymes in humans, and its overexpression delays endothelial cell growth and increases resistance to toxic challenges, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA, 31, Glutathione peroxidase 1 |
| Immunogen: |
An amino acid sequence from the middle region of human Glutathione peroxidase 1 (EVNGAGAHPLFAFLREALPAPSDDATALMTD) was used as the immunogen for this GPX1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the GPX1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
GPX1 |
| Short name: |
GPX1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
glutathione peroxidase 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
GPX1 and IDBG-305033 and ENSG00000233276 and 2876, GPXD and GSHPX1, Gpx1 and IDBG-199664 and ENSMUSG00000063856 and 14775, epigenetic and biological process this GO :0042311 and vasodilation and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042744 and hydrogen peroxide catabolic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043154 and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043295 and glutathione binding and molecular function this GO :0043403 and skeletal muscle tissue regeneration and biological process this GO :0043523 and regulation of neuron apoptotic process and biological process this GO :0043534 and blood vessel endothelial cell migration and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0045454 and cell redox homeostasis and biological process this GO :0047066 and phospholipid-hydroperoxide glutathione peroxidase activity and molecular function this GO :0048741 and skeletal muscle fiber development and biological process this GO :0051450 and myoblast proliferation and biological process this GO :0051593 and response to folic acid and biological process this GO :0051702 and interaction with symbiont and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0055086 and nucleobase-containing small molecule metabolic process and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0060047 and heart contraction and biological process this GO :0060055 and angiogenesis involved in wound healing and biological process this GO :0061136 and regulation of proteasomal protein catabolic process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0090201 and negative regulation of release of cytochrome c from mitochondria and biological process this GO :1902042 and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :1902176 and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and biological process, nuclei, phospholipid-hydroperoxide glutathione peroxidase activity, this GO :0000302 and response to reactive oxygen species and biological process this GO :0001659 and temperature homeostasis and biological process this GO :0001885 and endothelial cell development and biological process this GO :0002862 and negative regulation of inflammatory response to antigenic stimulus and biological process this GO :0004602 and glutathione peroxidase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005829 and cytosol and cellular component this GO :0006144 and purine nucleobase metabolic process and biological process this GO :0006195 and purine nucleotide catabolic process and biological process this GO :0006629 and lipid metabolic process and biological process this GO :0006641 and triglyceride metabolic process and biological process this GO :0006749 and glutathione metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0006982 and response to lipid hydroperoxide and biological process this GO :0007568 and aging and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0008283 and cell proliferation and biological process this GO :0008430 and selenium binding and molecular function this GO :0008631 and intrinsic apoptotic signaling pathway in response to oxidative stress and biological process this GO :0009410 and response to xenobiotic stimulus and biological process this GO :0009609 and response to symbiotic bacterium and biological process this GO :0009611 and response to wounding and biological process this GO :0009636 and response to toxic substance and biological process this GO :0009650 and UV protection and biological process this GO :0009725 and response to hormone and biological process this GO :0009749 and response to glucose and biological process this GO :0010269 and response to selenium ion and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0014902 and myotube differentiation and biological process this GO :0017124 and SH3 domain binding and molecular function this GO :0018158 and protein oxidation and biological process this GO :0019369 and arachidonic acid metabolic process and biological process this GO :0019372 and lipoxygenase pathway and biological process this GO :0032355 and response to estradiol and biological process this GO :0033194 and response to hydroperoxide and biological process this GO :0033599 and regulation of mammary gland epithelial cell proliferation and biological process this GO :0035094 and response to nicotine and biological process this GO :0040029 and regulation of gene expression, this GO :0004602 : glutathione peroxidase activity, this GO :0004602 : glutathione peroxidase activity and also this GO :0005515 : protein binding and also this GO :0008430 : selenium binding and also this GO :0017124 : SH3 domain binding and also this GO :0043295 : glutathione binding and also this GO :0047066 : phospholipid-hydroperoxide glutathione peroxidase activity, this GO :0005515 : protein binding, this GO :0008430 : selenium binding, this GO :0017124 : SH3 domain binding, this GO :0043295 : glutathione binding, this GO :0047066 : phospholipid-hydroperoxide glutathione peroxidase activity, glutathione peroxidase 1 |
| Identity: |
4553 |
| Gene: |
GPX1 |
More about : GPX1 |
| Long gene name: |
glutathione peroxidase 1 |
| Locus: |
3p21, 31 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
2876 |
| Pubmed identfication: |
9605859 |
| RefSeq identity: |
NM_000581 |
| Classification: |
Selenoproteins |
| Havana BLAST/BLAT: |
OTTHUMG00000156837 |