| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
VWF |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the VWF antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This VWF antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
7450 |
| Purity: |
Antigen affinity |
| Description: |
It is mapped to 12p13, The gene encodes a large multimeric glycoprotein that plays a central role in the blood coagulation system, VWF deficiency or dysfunction (von Willebrand disease) leads to a bleeding tendency, VWF released from endothelial cell Weibel-Palade bodies bound particularly avidly to the extracellular matrix, and as a carrier for coagulation factor VIII, serving both as a major mediator of platelet-vessel wall interaction and platelet adhesion, which is most apparent in tissues having high blood flow shear in narrow vessels, 31, Von Willebrand factor (VWF) is a blood glycoprotein involved in hemostasis |
| Immunogen: |
Human partial recombinant protein (AA 2535-2813) was used as the immunogen for this VWF antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the VWF antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
VWF |
| Short name: |
VWF Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
von Willebrand factor (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, F8VWF and VWD, VWF and IDBG-13506 and ENSG00000110799 and 7450, VWF and IDBG-640531 and ENSBTAG00000012265 and 280958, Vwf and IDBG-189967 and ENSMUSG00000001930 and 22371, chaperone binding, intrinsic pathway and biological process this GO :0007599 and hemostasis and biological process this GO :0009611 and response to wounding and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0019865 and immunoglobulin binding and molecular function this GO :0030168 and platelet activation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0031012 and extracellular matrix and cellular component this GO :0031091 and platelet alpha granule and cellular component this GO :0031093 and platelet alpha granule lumen and cellular component this GO :0031589 and cell-substrate adhesion and biological process this GO :0033093 and Weibel-Palade body and cellular component this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0047485 and protein N-terminus binding and molecular function this GO :0051087 and chaperone binding and molecular function this GO :0051260 and protein homooli this GO merization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0001889 and liver development and biological process this GO :0001890 and placenta development and biological process this GO :0001948 and glycoprotein binding and molecular function this GO :0002020 and protease binding and molecular function this GO :0002576 and platelet degranulation and biological process this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005518 and collagen binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007596 and blood coagulation and biological process this GO :0007597 and blood coagulation, this GO :0001948 : glycoprotein binding, this GO :0001948 : glycoprotein binding and also this GO :0002020 : protease binding and also this GO :0005178 : integrin binding and also this GO :0005515 : protein binding and also this GO :0005518 : collagen binding and also this GO :0019865 : immunoglobulin binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0047485 : protein N-terminus binding and also this GO :0051087 : chaperone binding, this GO :0002020 : protease binding, this GO :0005178 : integrin binding, this GO :0005515 : protein binding, this GO :0005518 : collagen binding, this GO :0019865 : immunoglobulin binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0047485 : protein N-terminus binding, this GO :0051087 : chaperone binding, von Willebrand factor |
| Identity: |
12726 |
| Gene: |
VWF |
More about : VWF |
| Long gene name: |
von Willebrand factor |
| Synonyms gene: |
F8VWF |
| Locus: |
12p13, 31 |
| Discovery year: |
1986-01-01 |
| Entrez gene record: |
7450 |
| Pubmed identfication: |
2251280 |
| RefSeq identity: |
NM_000552 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000168265 |
| Locus Specific Databases: |
Von Willebrand Factor Database LRG_587 |